Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

CREB binding protein (CBP) and p300 were both identified initially in protein interaction
assays–the former through its association with the transcription factor CREB (Chrivia et al …

Histone acetylation is important in chromatin remodelling and gene activation,,,. Nearly all
known histone-acetyltransferase (HAT)-associated transcriptional co-activators contain …

Nuclear receptors (NR) comprise a family of transcription factors that regulate gene
expression in a liganddependent manner. Members of the NR superfamily include receptors …

With the recent recognition of non-coding RNAs (ncRNAs) flanking many genes,,,,, a central
issue is to obtain a full understanding of their potential roles in regulated gene transcription …

Background Nrf2 belongs to the Cap‐N‐Collar (CNC) transcription factor family and is
essential for the antioxidant responsive element (ARE)‐mediated expression of a group of …

The cytokines LIF (leukemia inhibitory factor) and BMP2 (bone morphogenetic protein–2)
signal through different receptors and transcription factors, namely STATs (signal …

In eukaryotic cells, gene transcription is regulated by sequence-specific DNA-binding
transcription factors that recognize promoter and enhancer elements near the transcriptional …

Transcriptional coactivators have been viewed as constitutively active components, using
transcription factors mainly to localize their functions. Here, it is shown that PPARγ …

The transcriptional coactivators CREB binding protein (CBP) and p300 are key regulators of
RNA polymerase II-mediated transcription. Genetic alterations in the genes encoding these …