Diaphragm weakness is highly prevalent in critically ill patients. It may exist prior to ICU
admission and may precipitate the need for mechanical ventilation but it also frequently …

Skeletal muscle dysfunction occurs in patients with chronic obstructive pulmonary disease
(COPD) and affects both ventilatory and nonventilatory muscle groups. It represents a very …

Rationale: Intensive care unit (ICU)-and mechanical ventilation (MV)-acquired limb muscle
and diaphragm dysfunction may both be associated with longer length of stay and worse …

Levosimendan was first approved for clinical use in 2000, when authorization was granted
by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely …

Nemaline myopathies are a heterogenous group of congenital myopathies caused by de
novo, dominantly or recessively inherited mutations in at least twelve genes. The genes …

Rationale: The clinical significance of diaphragm weakness in critically ill patients is evident:
it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To …

Intensive care unit–acquired weakness (ICU-AW) is the most common neuromuscular
impairment in critically ill patients. We discuss critical aspects of ICU-AW that have not been …

The publication of the Spanish guideline for chronic obstructive pulmonary disease–COPD–
(GesEPOC) has brought about a change in the approach to the treatment of this disease …

Evidence has accumulated that respiratory muscle dysfunction develops in critically ill
patients and contributes to prolonged weaning from mechanical ventilation. Accordingly, it …

In the next decade, Chronic Obstructive Pulmonary Disease (COPD) will be a major leading
cause of death worldwide. Impaired muscle function and mass are common systemic …