Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to
what extent vancomycin is directly responsible, as numerous potential risk factors for acute …

Objectives: The objective of this systematic review and meta-analysis was to assess acute
kidney injury with combination therapy of vancomycin plus piperacillin-tazobactam, in …

Background This study analyzed the relationship between vancomycin area under the
concentration-time curve (AUC) and acute kidney injury (AKI) reported across recent studies …

Drug induced kidney injury is a frequent adverse event which contributes to morbidity and
increased healthcare utilization. Our current knowledge of drug induced kidney disease is …

The increasing number of infections produced by beta-lactam–resistant Gram-positive
bacteria and the morbidity secondary to these infections make it necessary to optimize the …

Vancomycin is a widely prescribed antibiotic, but the exact nature of vancomycin-associated
nephrotoxicity is unclear, in particular when considering the frequent coadministration of …

Purpose The goal of this review is to explore the role of antimicrobial therapeutic drug
monitoring (TDM), especially in critically ill, obese, and older adults, with a specific focus on …

Background Findings from previous studies have suggested that outcomes after meticillin-
resistant Staphylococcus aureus (MRSA) bacteraemia are worse than after meticillin …

Antibiotic-associated acute kidney injury (AA-AKI) is quite common, especially among
hospitalized patients; however, little is known about risk factors or mechanisms of why AA …

Vancomycin has been in clinical use for over 60 years, during which time renal toxicity has
been well documented. Multiple risk factors and outcomes are associated with vancomycin …