Infections represent a common health problem in people of all ages. Usually, the response
given to them is appropriate and so little treatment is needed. Sometimes, however, the …

Rapid and accurate profiling of infection-causing pathogens remains a significant challenge
in modern health care. Despite advances in molecular diagnostic techniques, blood culture …

Importance Sepsis is present in many hospitalizations that culminate in death. The
contribution of sepsis to these deaths, and the extent to which they are preventable, is …

Study objective Sepsis is a common and major health crisis in hospitals globally. An
innovative and feasible tool for predicting sepsis remains elusive. However, early and …

We carried out integrated host and pathogen metagenomic RNA and DNA next generation
sequencing (mNGS) of whole blood (n= 221) and plasma (n= 138) from critically ill patients …

Objectives: To specify when delays of specific 3-hour bundle Surviving Sepsis Campaign
guideline recommendations applied to severe sepsis or septic shock become harmful and …

Background We examined the risk of sepsis within 90 days after discharge from a previous
hospital stay by type of antibiotic received during the previous stay. Methods We …

Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,
increasing vascular permeability, promoting activation of the coagulation cascade, tissue …

Summary Sepsisshouldbedefinedaslife-threateningorgandysfunctioncausedbyadys…. Antibioticsarethecornerstoneofthetreatment…
. TheSurviving SepsisCampaign (SSC) recommendsthatcliniciansshouldperformem …

OBJECTIVES: To determine whether IV vitamin C therapy reduces 28-day mortality in
patients with septic shock. DESIGN: Multicenter, double-blinded, randomized controlled trial …