Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity

AI Abushouk, A Ismail, AMA Salem, AM Afifi… - Biomedicine & …, 2017 - Elsevier
Doxorubicin (DOX) is an anthracycline antibiotic, which is effectively used in the treatment of
different malignancies, such as leukemias and lymphomas. Its most serious side effect is …

Vaccinium myrtillus L. fruits as a novel source of phenolic compounds with health benefits and industrial applications-a review

TCSP Pires, C Caleja, C Santos-Buelga… - Current …, 2020 - ingentaconnect.com
Consumers' demand for healthier foods with functional properties has had a clear influence
on the food industry and in this sense, they have been attaching natural sources of bioactive …

Anti-Inflammatory Activity of Bilberry (Vaccinium myrtillus L.)

A Sharma, HJ Lee - Current issues in molecular biology, 2022 - mdpi.com
Inflammation is important in the pathogenesis of several chronic diseases. The anti-
inflammatory properties of berries have been investigated but the anti-inflammatory activity …

Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis—An open pilot study

L Biedermann, J Mwinyi, M Scharl, P Frei… - Journal of Crohn's …, 2013 - academic.oup.com
Background and aims: A significant fraction of patients with ulcerative colitis (UC) is not
sufficiently controlled with conventional therapy or suffers from therapy related side effects …

Vaccinium uliginosum and Vaccinium myrtillus—Two Species—One Used as a Functional Food

A Kopystecka, I Kozioł, D Radomska, K Bielawski… - Nutrients, 2023 - mdpi.com
Vaccinium uliginosum L.(commonly known as bog bilberry) and Vaccinium myrtillus
L.(commonly known as bilberry) are species of the genus Vaccinium (family Ericaceae). The …

Thymol and carvacrol prevent doxorubicin‐induced cardiotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats

ESM El‐Sayed, AM Mansour… - … of biochemical and …, 2016 - Wiley Online Library
The aim of this study was to assess the possible protective effects of thymol and carvacrol
(CAR) against doxorubicin (DOX)‐induced cardiotoxicity. A single dose of DOX (10 mg/kg iv) …

Nicorandil combats doxorubicin–induced nephrotoxicity via amendment of TLR4/P38 MAPK/NFκ-B signaling pathway

A Khames, MM Khalaf, AM Gad… - Chemico-biological …, 2019 - Elsevier
Nicorandil ameliorated doxorubicin-induced nephrotoxicity; this study aimed to show and
explain the mechanism of this protection. A precise method was elucidated to study the …

Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice

K Petroni, M Trinei, M Fornari, V Calvenzani… - Nutrition, metabolism …, 2017 - Elsevier
Background and aims Anthracyclines are effective anticancer drugs that have improved
prognosis of hundred thousand cancer patients worldwide and are currently the most …

Efficacy of procyanidins against in vivo cellular oxidative damage: a systematic review and meta-analysis

S Li, M Xu, Q Niu, S Xu, Y Ding, Y Yan, S Guo, F Li - PLoS One, 2015 - journals.plos.org
Aims In this study, the efficacy of proanthocyanidins (PCs) against oxidative damage was
systematically reviewed to facilitate their use in various applications. Methods A meta …

All-trans-retinoic acid ameliorates doxorubicin-induced cardiotoxicity: in vivo potential involvement of oxidative stress, inflammation, and apoptosis via caspase-3 and …

AF Khafaga, YS El-Sayed - Naunyn-Schmiedeberg's archives of …, 2018 - Springer
The present study aimed to investigate the potential protective effect of all-trans-retinoic acid
(ATRA, a natural derivative of vitamin A) against doxorubicin (DOX)-induced in vivo cardiac …