Toward automated enzymatic synthesis of oligosaccharides

L Wen, G Edmunds, C Gibbons, J Zhang… - Chemical …, 2018 - ACS Publications
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …

Virus-like particle vaccines: immunology and formulation for clinical translation

B Donaldson, Z Lateef, GF Walker… - Expert review of …, 2018 - Taylor & Francis
Introduction: Virus-like particle (VLP) vaccines face significant challenges in their translation
from laboratory models, to routine clinical administration. While some VLP vaccines thrive …

Emergence and significance of carbohydrate-specific antibodies

K Kappler, T Hennet - Genes & Immunity, 2020 - nature.com
Carbohydrate-specific antibodies are widespread among all classes of immunoglobulins.
Despite their broad occurrence, little is known about their formation and biological …

Precise assembly of proteins and carbohydrates for next-generation biomaterials

L Li, G Chen - Journal of the American Chemical Society, 2022 - ACS Publications
The complexity and diversity of biomacromolecules make them a unique class of building
blocks for generating precise assemblies. They are particularly available to a new …

Tick saliva and the alpha-gal syndrome: finding a needle in a haystack

SR Sharma, S Karim - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Ticks and tick-borne diseases are significant public health concerns. Bioactive molecules in
tick saliva facilitate prolonged blood-feeding and transmission of tick-borne pathogens to the …

Anti-Tick Microbiota Vaccine Impacts Ixodes ricinus Performance during Feeding

L Mateos-Hernández, D Obregón, J Maye, J Borneres… - Vaccines, 2020 - mdpi.com
The tick microbiota is a highly complex ensemble of interacting microorganisms. Keystone
taxa, with a central role in the microbial networks, support the stability and fitness of the …

Environmental and molecular drivers of the α-Gal syndrome

A Cabezas-Cruz, A Hodžić… - Frontiers in …, 2019 - frontiersin.org
The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody (Ab)
response against the carbohydrate Galα1-3Galβ1-4GlcNAc-R (α-Gal), which is present in …

The α-Gal syndrome and potential mechanisms

P Román-Carrasco, W Hemmer, A Cabezas-Cruz… - Frontiers in …, 2021 - frontiersin.org
The α-Gal syndrome is a complex allergic disease characterized by the development of
specific IgE antibodies against the carbohydrate galactose-α-1, 3-galactose (α-Gal), an …

Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

H Jamshaid, FU Din, GM Khan - Journal of Nanobiotechnology, 2021 - Springer
As a neglected tropical disease, Leishmaniasis is significantly instigating morbidity and
mortality across the globe. Its clinical spectrum varies from ulcerative cutaneous lesions to …

Topical review on nano-vaccinology: Biochemical promises and key challenges

T Zaheer, K Pal, I Zaheer - Process Biochemistry, 2021 - Elsevier
Nanomaterials have wide-ranging biomedical applications in prevention, treatment and
control of diseases. Nanoparticle based vaccines have proven prodigious prophylaxis of …