Podophyllotoxin, along with its various derivatives and congeners are widely recognized as
broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the …

Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared
from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity …

Cancer is a major killer disease all over the world and more than six million new cases are
reported every year. Nature is an attractive source of new therapeutic compounds, as a …

Lignans are found in a wide variety of plant species. The lignan podophyllotoxin is of special
interest, since its derivatives like eg etopophos® are used in anticancer therapy. As …

The natural lignan podophyllotoxin, a dimerized product of two phenylpropanoid moieties
which occurs in a few plant species, is a pharmacologically important compound for its …

Biotechnological production of plant-based secondary metabolites by a cell culture-based
bioprocess generally suffers from an inherent disadvantage of low yield. In order to …

Sinopodophyllum hexandrum is an alpine medicinal plant that produces the anticancer
compound podophyllotoxin (PPT). Although a positive relationship between PPT content …

Podophyllum hexandrum Royle is known for its vast medicinal properties, particularly
anticancer. It contains higher amount of podophyllotoxin (4.3%), compared to Podophyllum …

Adventitious root cultures of medicinal plants are a source of secondary metabolites of
pharmaceutical importance. Ophiorrhiza mungos (Rubiaceae) contains a bioactive …

The accumulation of podophyllotoxin (PTOX) and 6-methoxypodophyllotoxin (6MPTOX) was
enhanced about twofold in the suspension culture of Linum album line 2-5 aH following the …