The human body involves a large number of systems subjected to contact stresses and thus
experiencing wear and degradation. The limited efficacy of existing solutions constantly puts …

Devices that function in contact with blood are ubiquitous in clinical medicine and
biotechnology. These devices include vascular grafts, coronary stents, heart valves …

Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging,
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …

Opinion statement Early recognition of group A streptococcal pharyngitis and appropriate
management with benzathine penicillin using local clinical prediction rules together with …

Efficient function and long-term durability without the need for anticoagulation, coupled with
the ability to be accommodated in many different types of patient, are the principal …

The aortic valve regulates unidirectional flow of oxygenated blood to the myocardium and
arterial system. The natural anatomical geometry and microstructural complexity ensures …

Over 4 million people worldwide have received a prosthetic heart valve, and an estimated
300 000 valves are being implanted every year. Prosthetic heart valves improve quality of …

Regenerative medicine technologies rely heavily on the use of well‐designed biomaterials
for therapeutic applications. The success of implantable biomaterials hinges upon the ability …

Bovine pericardium is a collagenous tissue commonly used as a natural biomaterial in the
fabrication of cardiovascular devices. For tissue engineering purposes, this xenogeneic …

Synthetic implants made by traditional fabrication routes are not patient specific and rarely
match the performance of their biological counterparts. We present an additive …