Social connections are vital to survival throughout the animal kingdom and are dynamic
across the life span. There are debilitating consequences of social isolation and loneliness …

Behavioral states alternate between wakefulness and sleep, which is further subdivided into
rapid-eye-movement sleep and non-rapid-eye-movement sleep. Waking and sleep states …

Response gain is a crucial means by which modulatory systems control the impact of
sensory input. In the visual cortex, the serotonergic 5-HT2A receptor is key in such …

Circadian clocks generate rhythms of arousal, but the underlying molecular and cellular
mechanisms remain unclear. In Drosophila, the clock output molecule WIDE AWAKE …

Modafinil (MOD) is a wakefulness-inducing compound prescribed for treatment of excessive
daytime sleepiness as a consequence of sleep disturbances such as shift work sleep …

The lateral hypothalamus is comprised of a heterogeneous mix of neurons that serve to
integrate and regulate sleep, feeding, stress, energy balance, reward, and motivated …

Controlling gain of cortical activity is essential to modulate weights between internal ongoing
communication and external sensory drive. Here, we show that serotonergic input has …

Abstract Study Objectives To present results from in vivo studies underlying the preclinical
development of lemborexant (E2006), a novel dual orexin (hypocretin) receptor antagonist …

The hypocretin (Hcrt) system has been implicated in a wide range of physiological functions
from sleep-wake regulation to cardiovascular, behavioral, metabolic, and thermoregulagtory …

Optogenetics has recently gained recognition as a biological technique to control the activity
of cells using light stimulation. Many studies have applied optogenetics to cell lines in the …