Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

Spatial transcriptomics allows for the measurement of RNA abundance at a high spatial
resolution, making it possible to systematically link the morphology of cellular …

Cancer-associated fibroblasts (CAFs) are essential for tumor microenvironment remodeling
and correlate with tumor progression. However, interactions between CAFs and tumor cells …

Rationale: The tumor microenvironment (TME) determines tumor progression and affects
clinical therapy. Its basic components include cancer-associated fibroblasts (CAFs) and …

Inflammation and autophagy have emerged as prominent issues in the context of
proteoglycan signaling. In particular, two small, leucine‐rich proteoglycans, biglycan and …

Tumor blood vessels supply nutrients and oxygen to tumor cells for their growth and provide
routes for them to enter circulation. Thus, angiogenesis, the formation of new blood vessels …

Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …

Tumour blood vessels are gateways for distant metastasis. Recent studies have revealed
that tumour endothelial cells (TECs) demonstrate distinct phenotypes from their normal …

Angiogenesis, the formation of new blood vessels from preexisting one, represents a critical
process for oxygen and nutrient supply to proliferating cells, therefore promoting tumor …