SARS-CoV-2: Targeted managements and vaccine development

M Bakhiet, S Taurin - Cytokine & growth factor reviews, 2021 - Elsevier
Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) results in
diverse outcomes. The symptoms appear to be more severe in males older than 65 and …

[HTML][HTML] Endothelial cells and SARS-CoV-2: An intimate relationship

LC Barbosa, TL Goncalves, LP de Araujo… - Vascular …, 2021 - Elsevier
Abstract Angiotensin-converting enzyme 2 (ACE2) is an important player of the renin-
angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II into …

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

F D'Agnillo, KA Walters, Y Xiao, ZM Sheng… - Science translational …, 2021 - science.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan …

A comparison of covid-19, sars and mers

T Hu, Y Liu, M Zhao, Q Zhuang, L Xu, Q He - PeerJ, 2020 - peerj.com
In mid-December 2019, a novel atypical pneumonia broke out in Wuhan, Hubei Province,
China and was caused by a newly identified coronavirus, initially termed 2019 Novel …

Dissemination of extreme levels of extracellular vesicles: tissue factor activity in patients with severe COVID-19

C Guervilly, A Bonifay, S Burtey, F Sabatier… - Blood …, 2021 - ashpublications.org
Abstract Coronavirus disease 2019 (COVID-19) has become one of the biggest public
health challenges of this century. Severe forms of the disease are associated with a thrombo …

Thromboembolic complications in critically ill COVID-19 patients are associated with impaired fibrinolysis

JM Kruse, A Magomedov, A Kurreck, FH Münch… - Critical Care, 2020 - Springer
Background There is emerging evidence for enhanced blood coagulation in coronavirus
2019 (COVID-19) patients, with thromboembolic complications contributing to morbidity and …

[HTML][HTML] A proposal for staging COVID‐19 coagulopathy

J Thachil, M Cushman, A Srivastava… - Research and practice …, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID‐19) is associated with significant
hypercoagulability. However, despite prophylactic anticoagulation, critically ill patients with …

The management of surgical patients in the emergency setting during COVID-19 pandemic: the WSES position paper

B De Simone, E Chouillard, M Sartelli, WL Biffl… - World Journal of …, 2021 - Springer
Background Since the COVID-19 pandemic has occurred, nations showed their
unpreparedness to deal with a mass casualty incident of this proportion and severity, which …

Study of alteplase for respiratory failure in SARS-CoV-2 COVID-19: a vanguard multicenter, rapidly adaptive, pragmatic, randomized controlled trial

CD Barrett, HB Moore, EE Moore, J Wang, N Hajizadeh… - Chest, 2022 - Elsevier
Background Pulmonary vascular microthrombi are a proposed mechanism of COVID-19
respiratory failure. We hypothesized that early administration of tissue plasminogen activator …

Plant molecular farming as a strategy against COVID-19–the Italian perspective

C Lico, L Santi, S Baschieri, E Noris… - Frontiers in plant …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than
37,000 people in Italy and has caused widespread socioeconomic disruption. Urgent …