The principles of directed cell migration

S SenGupta, CA Parent, JE Bear - Nature Reviews Molecular Cell …, 2021 - nature.com
Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

[HTML][HTML] Designing multigradient biomaterials for skin regeneration

M Rahmati, JJ Blaker, SP Lyngstadaas, JF Mano… - Materials Today …, 2020 - Elsevier
Skin defects are amongst the main causes of morbidity and mortality worldwide, which
account for significantly high socioeconomic costs. Today, much attention is being paid to …

Fibrous systems as potential solutions for tendon and ligament repair, healing, and regeneration

C Rinoldi, E Kijeńska‐Gawrońska… - Advanced …, 2021 - Wiley Online Library
Tendon and ligament injuries caused by trauma and degenerative diseases are frequent
and affect diverse groups of the population. Such injuries reduce musculoskeletal …

Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration

L Fu, Z Yang, C Gao, H Li, Z Yuan… - Regenerative …, 2020 - academic.oup.com
Due to the sophisticated hierarchical structure and limited reparability of articular cartilage
(AC), the ideal regeneration of AC defects has been a major challenge in the field of …

Converting 2D nanofiber membranes to 3D hierarchical assemblies with structural and compositional gradients regulates cell behavior

S Chen, A McCarthy, JV John, Y Su… - Advanced Materials, 2020 - Wiley Online Library
New methods are described for converting 2D electrospun nanofiber membranes to 3D
hierarchical assemblies with structural and compositional gradients. Pore‐size gradients are …

Extrusion-based 3D bioprinting of gradients of stiffness, cell density, and immobilized peptide using thermogelling hydrogels

M Kuzucu, G Vera, M Beaumont, S Fischer… - ACS Biomaterials …, 2021 - ACS Publications
To study biological processes in vitro, biomaterials-based engineering solutions to
reproduce the gradients observed in tissues are necessary. We present a platform for the 3D …

3D-Reactive printing of engineered alginate inks

L Sardelli, M Tunesi, F Briatico-Vangosa, P Petrini - Soft Matter, 2021 - pubs.rsc.org
Alginate is a common component of bioinks due to its well-described ionic crosslinking
mechanism and tunable viscoelastic properties. Extrusion-based 3D-printing of alginate inks …

Gradient porous structures of mycelium: a quantitative structure–mechanical property analysis

E Olivero, E Gawronska, P Manimuda, D Jivani… - Scientific Reports, 2023 - nature.com
Gradient porous structures (GPS) are characterized by structural variations along a specific
direction, leading to enhanced mechanical and functional properties compared to …

Triphasic 3D in vitro model of bone-tendon-muscle interfaces to study their regeneration

W Balestri, GJ Hickman, RH Morris, JA Hunt… - Cells, 2023 - mdpi.com
The transition areas between different tissues, known as tissue interfaces, have limited
ability to regenerate after damage, which can lead to incomplete healing. Previous studies …

Biofabrication strategies for musculoskeletal disorders: Evolution towards clinical applications

S Naghieh, G Lindberg, M Tamaddon, C Liu - Bioengineering, 2021 - mdpi.com
Biofabrication has emerged as an attractive strategy to personalise medical care and
provide new treatments for common organ damage or diseases. While it has made impactful …