Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …

Psychedelic drugs including psilocybin, N, N ʹ-dimethyltryptamine (DMT) and lysergic acid
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …

Psilocybin therapy shows antidepressant potential, but its therapeutic actions are not well
understood. We assessed the subacute impact of psilocybin on brain function in two clinical …

Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints
that the use of psychedelics can produce neural adaptations, although the extent and …

Classic psychedelics produce altered states of consciousness that individuals often interpret
as meaningful experiences. Across a number of human studies, when the participant-rated …

Background This study aimed to investigate the efficacy and safety of lysergic acid
diethylamide (LSD)–assisted therapy in patients who experienced anxiety with or without …

Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

Depression is a widespread and devastating mental illness and the search for rapid-acting
antidepressants remains critical. There is now exciting evidence that the psychedelic …

This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

This paper formulates the action of psychedelics by integrating the free-energy principle and
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …