Three decades of ultrasound contrast agents: a review of the past, present and future improvements

P Frinking, T Segers, Y Luan, F Tranquart - Ultrasound in medicine & …, 2020 - Elsevier
Initial reports from the 1960s describing the observations of ultrasound contrast
enhancement by tiny gaseous bubbles during echocardiographic examinations prompted …

Passive cavitation imaging with ultrasound arrays

VA Salgaonkar, S Datta, CK Holland… - The Journal of the …, 2009 - pubs.aip.org
A method is presented for passive imaging of cavitational acoustic emissions using an
ultrasound array, with potential application in real-time monitoring of ultrasound ablation. To …

An in vitro study of a phase-shift nanoemulsion: a potential nucleation agent for bubble-enhanced HIFU tumor ablation

P Zhang, T Porter - Ultrasound in medicine & biology, 2010 - Elsevier
Phase-shift nanoemulsions have the potential to nucleate bubbles and enhance high-
intensity focused ultrasound (HIFU) cancer therapy. This emulsion consists of albumin …

Gauging the likelihood of stable cavitation from ultrasound contrast agents

KB Bader, CK Holland - Physics in Medicine & Biology, 2012 - iopscience.iop.org
The mechanical index (MI) was formulated to gauge the likelihood of adverse bioeffects from
inertial cavitation. However, the MI formulation did not consider bubble activity from stable …

Influence of the bubble-bubble interaction on destruction of encapsulated microbubbles under ultrasound

K Yasui, J Lee, T Tuziuti, A Towata… - The Journal of the …, 2009 - pubs.aip.org
Influence of the bubble-bubble interaction on the pulsation of encapsulated microbubbles
has been studied by numerical simulations under the condition of the experiment reported …

Ultrasound-triggered release of recombinant tissue-type plasminogen activator from echogenic liposomes

DAB Smith, SS Vaidya, JA Kopechek, SL Huang… - Ultrasound in medicine …, 2010 - Elsevier
Echogenic liposomes (ELIP) were developed as ultrasound-triggered targeted drug or gene
delivery vehicles (Lanza et al. 1997; Huang et al. 2001). Recombinant tissue-type …

On the relationship between microbubble fragmentation, deflation and broadband superharmonic signal production

BD Lindsey, JD Rojas, PA Dayton - Ultrasound in medicine & biology, 2015 - Elsevier
Acoustic angiography imaging of microbubble contrast agents uses the superharmonic
energy produced from excited microbubbles and enables high-contrast, high-resolution …

Relationship between cavitation and loss of echogenicity from ultrasound contrast agents

K Radhakrishnan, KB Bader, KJ Haworth… - Physics in Medicine …, 2013 - iopscience.iop.org
Ultrasound contrast agents (UCAs) have the potential to nucleate cavitation and promote
both beneficial and deleterious bioeffects in vivo. Previous studies have elucidated the pulse …

Ultrasound‐mediated release of hydrophilic and lipophilic agents from echogenic liposomes

JA Kopechek, TM Abruzzo, B Wang… - … of Ultrasound in …, 2008 - Wiley Online Library
Objective. To achieve ultrasound‐controlled drug delivery using echogenic liposomes
(ELIPs), we assessed ultrasound‐triggered release of hydrophilic and lipophilic agents in …

Destruction thresholds of echogenic liposomes with clinical diagnostic ultrasound

DAB Smith, TM Porter, J Martinez, S Huang… - Ultrasound in medicine …, 2007 - Elsevier
Echogenic liposomes (ELIP) are submicron-sized phospholipid vesicles that contain both
gas and fluid. With antibody conjugation and drug incorporation, these liposomes can be …