Separation technologies for whey protein fractionation

GQ Chen, Y Qu, SL Gras, SE Kentish - Food Engineering Reviews, 2023 - Springer
Whey is a by-product of cheese, casein, and yogurt manufacture. It contains a mixture of
proteins that need to be isolated and purified to fully exploit their nutritional and functional …

The transition from resin chromatography to membrane adsorbers for protein separations at industrial scale

Y Qu, I Bekard, B Hunt, J Black, L Fabri… - Separation & …, 2024 - Taylor & Francis
Membrane adsorbers (MA) are emerging as alternative unit operations in high-value protein
separation due to their many benefits, including short residence times, low pressure drop …

Membrane chromatography and fractionation of proteins from whey—A review

A Nath, MM Zin, MA Molnár, S Bánvölgyi, I Gáspár… - Processes, 2022 - mdpi.com
Membrane chromatography (MC) is an emerging bioseparation technology combining the
principles of membrane filtration and chromatography. In this process, one type of molecule …

An updated analysis of viral clearance unit operations for biotechnology manufacturing

OO Ajayi, SA Johnson, T Faison, N Azer… - Current Research in …, 2022 - Elsevier
Viral contamination is a potential risk of using biotechnology products derived from
mammalian cell lines. Therefore, to provide assurance of the safety of these products …

The use of predictive models to develop chromatography-based purification processes

CR Bernau, M Knödler, J Emonts, RC Jäpel… - … in Bioengineering and …, 2022 - frontiersin.org
Chromatography is the workhorse of biopharmaceutical downstream processing because it
can selectively enrich a target product while removing impurities from complex feed streams …

Towards next generation high throughput ion exchange membranes for downstream bioprocessing: A review

X Yang, A Merenda, ALA Riyadh, LF Dumée… - Journal of Membrane …, 2022 - Elsevier
Membrane chromatography is recognised as a potential solution to streamline downstream
processing for protein purification, where ion exchange membrane chromatography (IEMC) …

Sustainable whey processing techniques: Innovations in derivative and beverage production

L Ayed, S M'hir, N Asses - Food Bioscience, 2023 - Elsevier
In the past, whey was often considered a by-product of cheese making with little nutritional
value. However, it is now recognized that each whey component has its own value. With the …

Affinity and Pseudo-Affinity Membrane Chromatography for Viral Vector and Vaccine Purifications: A Review

K Lothert, MW Wolff - Membranes, 2023 - mdpi.com
Several chromatographic approaches have been established over the last decades for the
production of pharmaceutically relevant viruses. Due to the large size of these products …

Selective separation of dye/salt mixture using diatomite-based sandwich-like membrane

AM Abou-Elanwar, J Oh, S Lee, Y Kim - Chemosphere, 2023 - Elsevier
A novel nanofiltration membrane was developed by entrapping a layer of modified
diatomaceous earth between two layers of electrospun polysulfone (E-PSf) nanofibers. The …

[HTML][HTML] Recent advances to accelerate purification process development: A review with a focus on vaccines

D Keulen, G Geldhof, O Le Bussy, M Pabst… - … of Chromatography A, 2022 - Elsevier
The safety requirements for vaccines are extremely high since they are administered to
healthy people. For that reason, vaccine development is time-consuming and very …