The Pharmacological Activities of Crocus sativus L.: A Review Based on the Mechanisms and Therapeutic Opportunities of its Phytoconstituents

M Butnariu, C Quispe, J Herrera-Bravo… - Oxidative medicine …, 2022 - Wiley Online Library
Crocus species are mainly distributed in North Africa, Southern and Central Europe, and
Western Asia, used in gardens and parks as ornamental plants, while Crocus sativus …

Saffron bioactives crocin, crocetin and safranal: Effect on oxidative stress and mechanisms of action

D Cerdá-Bernad, E Valero-Cases… - Critical reviews in …, 2022 - Taylor & Francis
Saffron (Crocus sativus L.) is used as a spice for its organoleptic characteristics related to its
coloring and flavoring properties, and it has been also used in traditional medicine to treat …

[HTML][HTML] The effects of Crocus sativus (saffron) and its constituents on nervous system: A review

MR Khazdair, MH Boskabady, M Hosseini… - Avicenna journal of …, 2015 - ncbi.nlm.nih.gov
Saffron or Crocus sativus L.(C. sativus) has been widely used as a medicinal plant to
promote human health, especially in Asia. The main components of saffron are crocin …

Quinolinic acid: an endogenous neurotoxin with multiple targets

R Lugo-Huitrón, P Ugalde Muñiz… - Oxidative medicine …, 2013 - Wiley Online Library
Quinolinic acid (QUIN), a neuroactive metabolite of the kynurenine pathway, is normally
presented in nanomolar concentrations in human brain and cerebrospinal fluid (CSF) and is …

[HTML][HTML] Association between chronic stress and Alzheimer's disease: Therapeutic effects of Saffron

M Saeedi, A Rashidy-Pour - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Chronic stress and high levels of glucocorticoids produce functional and structural changes
in brain and especially in the hippocampus, an important limbic system structure that plays a …

Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action

AL Lopresti, PD Drummond - … : Clinical and Experimental, 2014 - Wiley Online Library
Background Saffron, a spice derived from the flower of Crocus sativus, has now undergone
several trials examining its antidepressant effects and, in a recent meta‐analysis, was …

Potential role of phytochemical extract from saffron in development of functional foods and protection of brain‐related disorders

Z Maqbool, MS Arshad, A Ali, A Aziz… - Oxidative Medicine …, 2022 - Wiley Online Library
The present review is designed to measure the effects of saffron extract in functional foods
and its pharmacological properties against various disorders. Saffron is a traditional …

The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review

S Nanda, K Madan - Heliyon, 2021 - cell.com
Reactive oxygen species (ROS) are produced as a result of various environmental factors
and cellular metabolism reactions creating oxidative stress. The reversible oxidative …

Antiinflammatory, Antioxidant, and Immunomodulatory Effects of Crocus sativus L. and its Main Constituents

MH Boskabady, T Farkhondeh - Phytotherapy Research, 2016 - Wiley Online Library
Crocus sativus L.(C. sativus), commonly known as saffron, is used as a food additive,
preservative, and medicinal herb. Traditionally, it has been used as an alternative treatment …

A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents

F Anaeigoudari, A Anaeigoudari… - Physiological …, 2023 - Wiley Online Library
Application of herbal medicines in the treatment of diseases is in the center of attention of
medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the …