Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

Osteochondral defects are caused by injury to both the articular cartilage and subchondral
bone within skeletal joints. They can lead to irreversible joint damage and increase the risk …

The dynamic extracellular matrix (ECM) constantly affects the behaviors of cells. To mimic
the dynamics of ECM with controllable stiffness and energy dissipation, this study proposes …

Osteoarthritis (OA) is a chronic, progressive, multifactorial disease resulting in a progressive
loss of articular cartilage structure and function that is most common in middle-aged and …

Clinical therapeutics for the regeneration of osteochondral defects (OCD) in the early stages
of osteoarthritis remain an enormous challenge in orthopaedics. For in-depth studies of …

The application of hydrogels coupled with 3-dimensional (3D) printing technologies
represents a modern concept in scaffold development in cartilage tissue engineering (CTE) …

The use of engineered scaffolds or stem cells is investigated widely in the repair of injured
musculoskeletal tissue. However, the combined regeneration of hierarchical osteochondral …

The socioeconomic impact of osteochondral (OC) damage has been increasing steadily
over time in the global population, and the promise of tissue engineering in generating …

Cartilage is mainly composed of chondrocytes and the extracellular matrix (ECM), which
transmits important biochemical and biomechanical signals necessary for differentiation and …

Magnetic resonance imaging (MRI) is a common clinical practice to visualize defects and to
distinguish different tissue types and pathologies in the human body. So far, MRI data have …