Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Lymphoedema is the swelling of one or several parts of the body owing to lymph
accumulation in the extracellular space. It is often chronic, worsens if untreated, predisposes …

The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …

The lymphatic system is fundamentally important to cardiovascular disease, infection and
immunity, cancer, and probably obesity—the four major challenges in healthcare in the 21st …

Lymphatic anomalies include a variety of developmental and/or functional defects affecting
the lymphatic vessels: sporadic and familial forms of primary lymphedema, secondary …

Macular and cone/cone-rod dystrophies (MD/CCRD) demonstrate a broad genetic and
phenotypic heterogeneity, with retinal alterations solely or predominantly involving the …

Eg5, the product of Kif11 gene, also known as kinesin spindle protein, is a motor protein
involved in the proper establishment of a bipolar mitotic spindle. Eg5 is one of the 45 …

The genetic causes of malformations of cortical development (MCD) remain largely
unknown. Here we report the discovery of multiple pathogenic missense mutations in …

Embryonic neocortical development depends on balanced production of progenitors and
neurons. Genetic mutations disrupting progenitor mitosis frequently impair neurogenesis; …