Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction
pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these …

1. Introduction 22. Heterotrimeric G-protein structure 32.1. G-protein α subunit 32.2. G-
protein βγ dimer 82.3. Unique role of Gβ5 in complexes with RGS proteins 92.4 …

Heterotrimeric G proteins are molecular switches that control signal transduction. Ligand-
occupied, G protein-coupled receptors serve as the canonical guanine nucleotide exchange …

Background The details of the functional interaction between G proteins and the G protein
coupled receptors (GPCRs) have long been subjected to extensive investigations with …

Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt
ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G …

There is a pressing need for new molecular tools to target protein surfaces with high affinity
and specificity. Here, we describe cyclic messenger RNA display with a trillion-member …

G-protein-coupled receptors (GPCRs) serve as catalytic activators of heterotrimeric G-
proteins (Gαβγ) by exchanging GTP for the bound GDP on the Gα subunit. This guanine …

Abstract β-Ketoacyl CoA synthetase (KCS) is a key rate-limiting enzyme for the synthesis of
very-long-chain fatty acids (VLCFAs) in plants that determines the synthesis rate and carbon …

The coordinated cross-talk from heterotrimeric G proteins to Rho GTPases is essential
during a variety of physiological processes. Emerging data suggest that members of the Gα …

The book provides a comprehensive view of the impact and promise of phage display in
drug discovery and biotechnology. Building on the success of its previous edition, the book …