Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Mitochondrial fidelity is a key determinant of longevity and was found to be perturbed in a
multitude of disease contexts ranging from neurodegeneration to heart failure. Tight …

INTRODUCTION Mitochondria are dynamic organelles that coordinate many cellular
functions that are essential for life, including diverse metabolic processes, cell division and …

Hundreds of nucleus‐encoded mitochondrial precursor proteins are synthesized in the
cytosol and imported into mitochondria in a post‐translational manner. However, the early …

Eukaryotes organize cellular contents into membrane-bound organelles and membrane-
less condensates, for example, protein aggregates. An unsolved question is why the …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses high
amounts of the protein Orf9b to target the mitochondrial outer membrane protein Tom70 …

Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …

Viruses have developed different strategies to hijack mitophagy to facilitate their replication.
However, whether and how African swine fever virus (ASFV) regulates mitophagy are …

Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into
mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the …

Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis,
quality control, and signaling. The systematic analysis of protein complexes and interaction …