Molecular mechanisms of dietary restriction promoting health and longevity

CL Green, DW Lamming, L Fontana - Nature Reviews Molecular Cell …, 2022 - nature.com
Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Clinical application of intermittent fasting for weight loss: progress and future directions

KA Varady, S Cienfuegos, M Ezpeleta… - Nature Reviews …, 2022 - nature.com
Intermittent fasting diets have become very popular in the past few years, as they can
produce clinically significant weight loss. These diets can be defined, in the simplest of …

Effectiveness of early time-restricted eating for weight loss, fat loss, and cardiometabolic health in adults with obesity: a randomized clinical trial

H Jamshed, FL Steger, DR Bryan… - JAMA internal …, 2022 - jamanetwork.com
Importance It is unclear how effective intermittent fasting is for losing weight and body fat,
and the effects may depend on the timing of the eating window. This randomized trial …

Intermittent fasting and metabolic health

I Vasim, CN Majeed, MD DeBoer - Nutrients, 2022 - mdpi.com
Given the ongoing strain that the obesity epidemic has placed on public health outcomes,
new and effective approaches to weight control are needed. One approach to improving …

[HTML][HTML] Effects of 4-and 6-h time-restricted feeding on weight and cardiometabolic health: a randomized controlled trial in adults with obesity

S Cienfuegos, K Gabel, F Kalam, M Ezpeleta… - Cell metabolism, 2020 - cell.com
Time-restricted feeding (TRF) regimens have grown in popularity; however, very few studies
have examined their weight-loss efficacy. We conducted the first human trial (Clinicaltrials …

Cardiometabolic benefits of intermittent fasting

KA Varady, S Cienfuegos, M Ezpeleta… - Annual review of …, 2021 - annualreviews.org
This review aims to summarize the effects of intermittent fasting on markers of
cardiometabolic health in humans. All forms of fasting reviewed here—alternate-day fasting …

[HTML][HTML] Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes

EF Sutton, R Beyl, KS Early, WT Cefalu, E Ravussin… - Cell metabolism, 2018 - cell.com
Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether
these effects are due solely to weight loss. We conducted the first supervised controlled …

A time to fast

A Di Francesco, C Di Germanio, M Bernier, R De Cabo - Science, 2018 - science.org
Nutrient composition and caloric intake have traditionally been used to devise optimized
diets for various phases of life. Adjustment of meal size and frequency have emerged as …

Flipping the metabolic switch: understanding and applying the health benefits of fasting

SD Anton, K Moehl, WT Donahoo, K Marosi, SA Lee… - …, 2018 - Wiley Online Library
Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in
which no or few calories are consumed for time periods that can range from 12 hours to …

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022 - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …