microRNA strand selection: Unwinding the rules
Abstract microRNAs (miRNAs) play a central role in the regulation of gene expression by
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …
MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship
AE Pasquinelli - Nature Reviews Genetics, 2012 - nature.com
MicroRNAs (miRNAs) have emerged as key gene regulators in diverse biological pathways.
These small non-coding RNAs bind to target sequences in mRNAs, typically resulting in …
These small non-coding RNAs bind to target sequences in mRNAs, typically resulting in …
PDL1 Regulation by p53 via miR-34
Background: Although clinical studies have shown promise for targeting PD1/PDL1
signaling in non–small cell lung cancer (NSCLC), the regulation of PDL1 expression is …
signaling in non–small cell lung cancer (NSCLC), the regulation of PDL1 expression is …
[HTML][HTML] mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues
MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational
repression and mRNA destabilization, with mRNA destabilization dominating at steady state …
repression and mRNA destabilization, with mRNA destabilization dominating at steady state …
Gene silencing by microRNAs: contributions of translational repression and mRNA decay
E Huntzinger, E Izaurralde - Nature Reviews Genetics, 2011 - nature.com
Despite their widespread roles as regulators of gene expression, important questions
remain about target regulation by microRNAs. Animal microRNAs were originally thought to …
remain about target regulation by microRNAs. Animal microRNAs were originally thought to …
Regulation of mRNA translation and stability by microRNAs
MR Fabian, N Sonenberg… - Annual review of …, 2010 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …
[HTML][HTML] MicroRNAs: processing, maturation, target recognition and regulatory functions
The remarkable discovery of small noncoding microRNAs (miRNAs) and their role in
posttranscriptional gene regulation have revealed another fine-tuning step in the expression …
posttranscriptional gene regulation have revealed another fine-tuning step in the expression …
[HTML][HTML] MicroRNAs: synthesis, mechanism, function, and recent clinical trials
MicroRNAs (miRNAs) are a class of small, endogenous RNAs of 21–25 nucleotides (nts) in
length. They play an important regulatory role in animals and plants by targeting specific …
length. They play an important regulatory role in animals and plants by targeting specific …
[HTML][HTML] Origins and mechanisms of miRNAs and siRNAs
RW Carthew, EJ Sontheimer - Cell, 2009 - cell.com
Over the last decade,∼ 20–30 nucleotide RNA molecules have emerged as critical
regulators in the expression and function of eukaryotic genomes. Two primary categories of …
regulators in the expression and function of eukaryotic genomes. Two primary categories of …
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
W Filipowicz, SN Bhattacharyya… - Nature reviews …, 2008 - nature.com
MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding
RNAs that have emerged as key post-transcriptional regulators of gene expression in …
RNAs that have emerged as key post-transcriptional regulators of gene expression in …