Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders
A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …
applications have received much attention from the global scientific community in an …
Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases
CR Harrell, N Jovicic, V Djonov, N Arsenijevic… - Cells, 2019 - mdpi.com
There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression
was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC …
was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC …
Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome
CR Harrell, C Fellabaum, N Jovicic, V Djonov… - Cells, 2019 - mdpi.com
Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …
[HTML][HTML] Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives
CR Harrell, BS Markovic, C Fellabaum… - Biomedicine & …, 2019 - Elsevier
Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by
progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions …
progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions …
Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …
Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline …
Z Zhang, J Shang, Q Yang, Z Dai, Y Liang, C Lai… - Journal of …, 2023 - Springer
Liver fibrosis is a chronic liver disease with the presence of progressive wound healing
response caused by liver injury. Currently, there are no approved therapies for liver fibrosis …
response caused by liver injury. Currently, there are no approved therapies for liver fibrosis …
Neuroinflammation and scarring after spinal cord injury: therapeutic roles of MSCs on inflammation and glial scar
QM Pang, SY Chen, QJ Xu, SP Fu, YC Yang… - Frontiers in …, 2021 - frontiersin.org
Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is
thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may …
thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may …
Mesenchymal stem cell‐based therapy of inflammatory lung diseases: current understanding and future perspectives
CR Harrell, R Sadikot, J Pascual… - Stem cells …, 2019 - Wiley Online Library
During acute or chronic lung injury, inappropriate immune response and/or aberrant repair
process causes irreversible damage in lung tissue and most usually results in the …
process causes irreversible damage in lung tissue and most usually results in the …
[HTML][HTML] The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future
Y Watanabe, A Tsuchiya, S Terai - Clinical and molecular …, 2021 - ncbi.nlm.nih.gov
Cirrhosis is a chronic condition that can lead to liver failure. Currently, the viable option for
decreasing mortality is liver transplantation. However, transplant surgery is highly invasive …
decreasing mortality is liver transplantation. However, transplant surgery is highly invasive …
MSC spheroids-loaded collagen hydrogels simultaneously promote neuronal differentiation and suppress inflammatory reaction through PI3K-Akt signaling pathway
J He, N Zhang, Y Zhu, R Jin, F Wu - Biomaterials, 2021 - Elsevier
It is critical for the clinical success to take the anti-inflammatory function into consideration
when integrating the neurogenesis into the nerve repair materials. To this aim, we prepared …
when integrating the neurogenesis into the nerve repair materials. To this aim, we prepared …