One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate
the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during …

The development of persistent cellular reservoirs of latent human immunodeficiency virus
(HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti …

The relevance of monocyte and macrophage reservoirs in virally suppressed people with
HIV (vsPWH) has previously been debatable. Macrophages were assumed to have a …

Despite viral suppression with antiretroviral therapy (ART), people with human
immunodeficiency virus (HIV) continue to experience central nervous system (CNS) …

A cure for HIV infection remains elusive due to the persistence of replication-competent HIV
proviral DNA during suppressive antiretroviral therapy (ART). With the exception of rare elite …

Due to the increasing population of individuals with cardiovascular diseases and related
comorbidities, there is an increasing need for development of synergistic therapeutics …

Background Among people living with HIV-1 (PHIV), immunological non-responders (INR)
experience incomplete immune recovery despite suppressive antiretroviral treatment (ART) …

Immune reconstitution inflammatory syndrome (IRIS) presents as an exaggerated immune
reaction that occurs during dysregulated immune restoration in immunocompromised …

The lungs are relatively unexplored anatomical human immunodeficiency virus (HIV)
reservoirs in the antiretroviral therapy (ART) era. Double negative (DN) T cells are a subset …