A test in context: D-dimer
D-dimer is a soluble fibrin degradation product that results from ordered breakdown of
thrombi by the fibrinolytic system. Numerous studies have shown that D-dimer serves as a …
thrombi by the fibrinolytic system. Numerous studies have shown that D-dimer serves as a …
The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
The end of AIDS: HIV infection as a chronic disease
The success of antiretroviral therapy has led some people to now ask whether the end of
AIDS is possible. For patients who are motivated to take therapy and who have access to …
AIDS is possible. For patients who are motivated to take therapy and who have access to …
International AIDS Society global scientific strategy: towards an HIV cure 2016
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …
global population of more than 35 million people living with HIV, there is intense interest in …
HIV infection: epidemiology, pathogenesis, treatment, and prevention
G Maartens, C Celum, SR Lewin - The Lancet, 2014 - thelancet.com
HIV prevalence is increasing worldwide because people on antiretroviral therapy are living
longer, although new infections decreased from 3· 3 million in 2002, to 2· 3 million in 2012 …
longer, although new infections decreased from 3· 3 million in 2002, to 2· 3 million in 2012 …
Systemic effects of inflammation on health during chronic HIV infection
Combination antiretroviral therapy for HIV infection improves immune function and
eliminates the risk of AIDS-related complications but does not restore full health. HIV …
eliminates the risk of AIDS-related complications but does not restore full health. HIV …
Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
CV Fletcher, K Staskus, SW Wietgrefe… - Proceedings of the …, 2014 - National Acad Sciences
Antiretroviral therapy can reduce HIV-1 to undetectable levels in peripheral blood, but the
effectiveness of treatment in suppressing replication in lymphoid tissue reservoirs has not …
effectiveness of treatment in suppressing replication in lymphoid tissue reservoirs has not …
[HTML][HTML] Differential decay of intact and defective proviral DNA in HIV-1–infected individuals on suppressive antiretroviral therapy
MJ Peluso, P Bacchetti, KD Ritter, S Beg, J Lai… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND The relative stabilities of the intact and defective HIV genomes over time
during effective antiretroviral therapy (ART) have not been fully characterized. METHODS …
during effective antiretroviral therapy (ART) have not been fully characterized. METHODS …
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
The impact of HIV-and ART-induced mitochondrial dysfunction in cellular senescence and aging
M Schank, J Zhao, JP Moorman, ZQ Yao - Cells, 2021 - mdpi.com
According to the WHO, 38 million individuals were living with human immunodeficiency virus
(HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019 …
(HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019 …