Lipid rafts: controversies resolved, mysteries remain
The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …
biological membranes into domains of distinct structures, compositions, and functions. This …
Computational modeling of realistic cell membranes
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
[HTML][HTML] Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness
KR Levental, E Malmberg, JL Symons, YY Fan… - Nature …, 2020 - nature.com
Proper membrane physiology requires maintenance of biophysical properties, which must
be buffered from external perturbations. While homeostatic adaptation of membrane fluidity …
be buffered from external perturbations. While homeostatic adaptation of membrane fluidity …
Biological membrane organization and cellular signaling
To execute their many vital functions, cell membranes are highly organized. Here, we review
how membrane structure shapes signal transduction across membranes. Recent …
how membrane structure shapes signal transduction across membranes. Recent …
LiPyphilic: A Python toolkit for the analysis of lipid membrane simulations
Molecular dynamics simulations are now widely used to study emergent phenomena in lipid
membranes with complex compositions. Here, we present LiPyphilic—a fast, fully tested …
membranes with complex compositions. Here, we present LiPyphilic—a fast, fully tested …
ω-3 polyunsaturated fatty acids direct differentiation of the membrane phenotype in mesenchymal stem cells to potentiate osteogenesis
Mammalian cells produce hundreds of dynamically regulated lipid species that are actively
turned over and trafficked to produce functional membranes. These lipid repertoires are …
turned over and trafficked to produce functional membranes. These lipid repertoires are …
[HTML][HTML] Structure and dynamics of GPCRs in lipid membranes: physical principles and experimental approaches
Over the past decade, the vast amount of information generated through structural and
biophysical studies of GPCRs has provided unprecedented mechanistic insight into the …
biophysical studies of GPCRs has provided unprecedented mechanistic insight into the …
[HTML][HTML] EPA and DHA differentially modulate membrane elasticity in the presence of cholesterol
Polyunsaturated fatty acids (PUFAs) modify the activity of a wide range of membrane
proteins and are increasingly hypothesized to modulate protein activity by indirectly altering …
proteins and are increasingly hypothesized to modulate protein activity by indirectly altering …
Nonconverged constraints cause artificial temperature gradients in lipid bilayer simulations
Molecular dynamics (MD) simulations have become an indispensable tool to investigate
phase separation in model membrane systems. In particular, simulations based on coarse …
phase separation in model membrane systems. In particular, simulations based on coarse …