Double-strand break repair: 53BP1 comes into focus
S Panier, SJ Boulton - Nature reviews Molecular cell biology, 2014 - nature.com
DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic
integrity and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important …
integrity and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important …
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
P Schwertman, S Bekker-Jensen… - Nature reviews Molecular …, 2016 - nature.com
DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. The swift recognition
and faithful repair of such damage is crucial for the maintenance of genomic stability, as well …
and faithful repair of such damage is crucial for the maintenance of genomic stability, as well …
[HTML][HTML] Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
BF Py, MS Kim, H Vakifahmetoglu-Norberg, J Yuan - Molecular cell, 2013 - cell.com
NLRP3 is an important pattern recognition receptor involved in mediating inflammasome
activation in response to viral and bacterial infections as well as various proinflammatory …
activation in response to viral and bacterial infections as well as various proinflammatory …
Regulation of DNA damage responses by ubiquitin and SUMO
SP Jackson, D Durocher - Molecular cell, 2013 - cell.com
Ubiquitylation and sumoylation, the covalent attachment of the polypeptides ubiquitin and
SUMO, respectively, to target proteins, are pervasive mechanisms for controlling cellular …
SUMO, respectively, to target proteins, are pervasive mechanisms for controlling cellular …
Breaking the chains: structure and function of the deubiquitinases
Ubiquitylation is a reversible protein modification that is implicated in many cellular
functions. Recently, much progress has been made in the characterization of a superfamily …
functions. Recently, much progress has been made in the characterization of a superfamily …
The same, only different–DNA damage checkpoints and their reversal throughout the cell cycle
IA Shaltiel, L Krenning, W Bruinsma… - Journal of cell …, 2015 - journals.biologists.com
Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …
Deubiquitylases from genes to organism
Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …
cell physiology. It is reversed through the action of a large family of deubiquitylating …
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
J Lukas, C Lukas, J Bartek - Nature cell biology, 2011 - nature.com
Following the discovery in 1998 of γ-H2AX, the first histone modification induced by DNA
damage, interest in the changes to chromatin induced by DNA damage has exploded, and a …
damage, interest in the changes to chromatin induced by DNA damage has exploded, and a …
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair
H Yu, H Pak, I Hammond-Martel… - Proceedings of the …, 2014 - National Acad Sciences
The cellular response to highly genotoxic DNA double-strand breaks (DSBs) involves the
exquisite coordination of multiple signaling and repair factors. Here, we conducted a …
exquisite coordination of multiple signaling and repair factors. Here, we conducted a …
[HTML][HTML] Deubiquitinase inhibition as a cancer therapeutic strategy
P D'Arcy, X Wang, S Linder - Pharmacology & therapeutics, 2015 - Elsevier
The ubiquitin proteasome system (UPS) is the main system for controlled protein
degradation and a key regulator of fundamental cellular processes. The dependency of …
degradation and a key regulator of fundamental cellular processes. The dependency of …