Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for
change in the form of newer and more adaptive diagnostic methods for the detection of …
change in the form of newer and more adaptive diagnostic methods for the detection of …
Computational Methods in Immunology and Vaccinology: Design and Development of Antibodies and Immunogens
The design of new biomolecules able to harness immune mechanisms for the treatment of
diseases is a prime challenge for computational and simulative approaches. For instance, in …
diseases is a prime challenge for computational and simulative approaches. For instance, in …
Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?
RW Titball, MN Burtnick, GJ Bancroft, P Brett - Vaccine, 2017 - Elsevier
B. pseudomallei is the cause of melioidosis, a serious an often fatal disease of humans and
animals. The closely related bacterium B. mallei, which cases glanders, is considered to be …
animals. The closely related bacterium B. mallei, which cases glanders, is considered to be …
Structural and computational biology in the design of immunogenic vaccine antigens
L Liljeroos, E Malito, I Ferlenghi… - Journal of immunology …, 2015 - Wiley Online Library
Vaccination is historically one of the most important medical interventions for the prevention
of infectious disease. Previously, vaccines were typically made of rather crude mixtures of …
of infectious disease. Previously, vaccines were typically made of rather crude mixtures of …
The answer lies in the energy: how simple atomistic molecular dynamics simulations may hold the key to epitope prediction on the fully glycosylated SARS-CoV-2 …
SA Serapian, F Marchetti, A Triveri… - The Journal of …, 2020 - ACS Publications
SARS-CoV-2 is a health threat with dire socioeconomical consequences. As the crucial
mediator of infection, the viral glycosylated spike protein (S) has attracted the most attention …
mediator of infection, the viral glycosylated spike protein (S) has attracted the most attention …
Braun's lipoprotein facilitates OmpA interaction with the Escherichia coli cell wall
Gram-negative bacteria such as Escherichia coli are protected by a complex cell envelope.
The development of novel therapeutics against these bacteria necessitates a molecular …
The development of novel therapeutics against these bacteria necessitates a molecular …
SARS-CoV-2 spike protein mutations and escape from antibodies: a computational model of epitope loss in variants of concern
A Triveri, SA Serapian, F Marchetti… - Journal of Chemical …, 2021 - ACS Publications
The SARS-CoV-2 spike (S) protein is exposed on the viral surface and is the first point of
contact between the virus and the host. For these reasons it represents the prime target for …
contact between the virus and the host. For these reasons it represents the prime target for …
Current Advances in Burkholderia Vaccines Development
G Wang, P Zarodkiewicz, MA Valvano - Cells, 2020 - mdpi.com
The genus Burkholderia includes a wide range of Gram-negative bacterial species some of
which are pathogenic to humans and other vertebrates. The most pathogenic species are …
which are pathogenic to humans and other vertebrates. The most pathogenic species are …
Screening complex biological samples with peptide microarrays: the favorable impact of probe orientation via chemoselective immobilization strategies on clickable …
The generation of robust analytical data using microarray platforms strictly relies on optimal
ligand–target interaction at the sensor surface, which, in turn, is inherently bound to the …
ligand–target interaction at the sensor surface, which, in turn, is inherently bound to the …
The Burkholderia cenocepacia peptidoglycan‐associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation
R Dennehy, M Romano, A Ruggiero… - Cellular …, 2017 - Wiley Online Library
Abstract The Burkholderia cepacia complex (Bcc) is a group of Gram‐negative opportunistic
pathogens causing infections in people with cystic fibrosis (CF). Bcc is highly antibiotic …
pathogens causing infections in people with cystic fibrosis (CF). Bcc is highly antibiotic …