Neuropathic pain, a disease of the somatosensory nervous system, afflicts many individuals
and adequate management with current pharmacotherapies remains elusive. The …

Melatonin (MLT) has been implicated in several pathophysiological states, including pain.
MLT mostly activates two G-protein coupled receptors, MT1 and MT2. In this review, we …

In search of new dual-acting histamine H3/sigma-1 receptor ligands, we designed a series
of compounds structurally based on highly active in vivo ligands previously studied and …

Toll-like receptors (TLRs) are key receptors through which infectious and non-infectious
challenges act with consequent activation of the inflammatory cascade that plays a critical …

To improve the oral absorption of fish oil and test its anti-inflammatory effect, a fish oil
nanoemulsion was developed using cis-4, 7, 10, 13, 16, 19-docosahexaenoic fatty acid as a …

Nociceptive signals originating in the periphery are conveyed to the brain through specific
afferent and ascending pathways. The spino-(trigemino-) parabrachio-amygdaloid pathway …

The synthesis of a novel cyclohexanone derivative (CHD; Ethyl 6-(4-metohxyphenyl)-2-oxo-
4-phenylcyclohexe-3-enecarboxylate) was described and the subsequent aim was to …

Improved living conditions have induced an increase of lifespan often accompanied by
comorbidities, responsible for pain, and by cognitive impairment and dementia, impairing …

Thymoquinone (TQ), an active constituent of Nigella sativa, has been reported to exert a
broad spectrum of pharmacological effects, including neuroprotective, anticancer, anti …

Background Curcumin has antioxidative properties that could be useful in various diseases
due to its ability to act on multiple targets of various cellular pathways. We aimed to assess …