Molecular mechanisms of prion pathogenesis

A Aguzzi, C Sigurdson… - Annu. Rev. Pathol. Mech …, 2008 - annualreviews.org
Prion diseases are infectious neurodegenerative diseases occurring in humans and animals
with an invariably lethal outcome. One fundamental mechanistic event in prion diseases is …

Atypical/Nor98 scrapie: properties of the agent, genetics, and epidemiology

S Benestad, JN Arsac, W Goldmann, M Nöremark - Veterinary research, 2008 - hal.science
Atypical/Nor98 scrapie cases in sheep were diagnosed for the first time in Norway in 1998.
They are now identified in small ruminants in most European countries and represent an …

Update on classical and atypical scrapie in sheep and goats

JJ Greenlee - Veterinary pathology, 2019 - journals.sagepub.com
Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) or prion
disease of sheep and goats. Scrapie is a protein misfolding disease where the normal prion …

The expanding universe of prion diseases

JC Watts, A Balachandran, D Westaway - PLoS pathogens, 2006 - journals.plos.org
Prions cause fatal and transmissible neurodegenerative disease. These etiological
infectious agents are formed in greater part from a misfolded cell-surface protein called …

A descriptive study of the prevalence of atypical and classical scrapie in sheep in 20 European countries

A Fediaevsky, SC Tongue, M Nöremark… - BMC veterinary …, 2008 - Springer
Background The development of active surveillance programmes for transmissible
spongiform encephalopathies of small ruminants across Europe has led to the recent …

Diagnosis of transmissible spongiform encephalopathies in animals: a review

D Gavier-Widén, MJ Stack, T Baron… - Journal of …, 2005 - journals.sagepub.com
Transmissible spongiform encephalopathies (TSEs) in animals include, among others,
bovine spongiform encephalopathy (BSE), scrapie, chronic wasting disease, and atypical …

PrP genotypes of atypical scrapie cases in Great Britain

GC Saunders, S Cawthraw… - Journal of General …, 2006 - microbiologyresearch.org
Great Britain and elsewhere have detected atypical scrapie infection in sheep with PrP
genotypes thought to be genetically resistant to the classical form of scrapie. DNA …

[HTML][HTML] Similar biochemical signatures and prion protein genotypes in atypical scrapie and Nor98 cases, France and Norway

JN Arsac, O Andreoletti, JM Bilheude… - Emerging infectious …, 2007 - ncbi.nlm.nih.gov
Isolates of atypical scrapie recently identified in sheep and goats in France were compared
with Nor98 isolates reported in Norway. Western blot methods for characterization of the …

Prion protein misfolding, strains, and neurotoxicity: an update from studies on mammalian prions

I Poggiolini, D Saverioni… - International journal of cell …, 2013 - Wiley Online Library
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are a
group of fatal neurodegenerative disorders affecting humans and other mammalian species …

The transmissible spongiform encephalopathies of livestock

JJ Greenlee, MHW Greenlee - ILAR journal, 2015 - academic.oup.com
Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal protein-
misfolding neurodegenerative diseases. TSEs have been described in several species …