Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease

EF Balcom, A Nath, C Power - Brain, 2021 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19) is a global pandemic caused by SARS-CoV-
2 infection and is associated with both acute and chronic disorders affecting the nervous …

CSF biomarkers in COVID-19 associated encephalopathy and encephalitis predict long-term outcome

M Guasp, G Muñoz-Sánchez… - Frontiers in …, 2022 - frontiersin.org
Patients with coronavirus disease 2019 (COVID-19) frequently develop acute
encephalopathy and encephalitis, but whether these complications are the result from viral …

Plasma markers of neurologic injury and inflammation in people with self-reported neurologic postacute sequelae of SARS-CoV-2 infection

MJ Peluso, HM Sans, CA Forman… - Neurology …, 2022 - AAN Enterprises
Background and Objectives The biologic mechanisms underlying neurologic postacute
sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Inflammation at the crossroads of COVID-19, cognitive deficits and depression

NML e Silva, FGQ Barros-Aragão, FG De Felice… - …, 2022 - Elsevier
Acute neurological alterations have been associated with SARS-CoV-2 infection.
Additionally, it is becoming clear that coronavirus disease 2019 (COVID-19) survivors may …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

Neurotropism of SARS-CoV-2 and neurological diseases of the central nervous system in COVID-19 patients

S Veleri - Experimental brain research, 2022 - Springer
The devastating COVID-19 pandemic is caused by the SARS-CoV-2 virus. It primarily affects
the lung and induces acute respiratory distress leading to a decrease in oxygen supply to …

Cerebrospinal fluid in COVID-19 neurological complications: Neuroaxonal damage, anti-SARS-Cov2 antibodies but no evidence of cytokine storm

MA Garcia, PV Barreras, A Lewis, G Pinilla… - Journal of the …, 2021 - Elsevier
Objective To study in cerebrospinal fluid (CSF) of COVID-19 subjects if a “cytokine storm” or
neuroinflammation are implicated in pathogenesis of neurological complications. Methods …

Brain imaging and neuropsychological assessment of individuals recovered from a mild to moderate SARS-CoV-2 infection

M Petersen, FL Nägele, C Mayer… - Proceedings of the …, 2023 - National Acad Sciences
As severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infections have
been shown to affect the central nervous system, the investigation of associated alterations …

Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms

A Borsini, B Merrick, J Edgeworth, G Mandal… - Molecular …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), represents an enormous new threat to our
healthcare system and particularly to the health of older adults. Although the respiratory …