Medicinal chemistry of oxazines as promising agents in drug discovery

DS Zinad, A Mahal, RK Mohapatra… - Chemical biology & …, 2020 - Wiley Online Library
Oxazines have brought much synthetic interest due to their extensive biological activities.
These are the important category of heterocycles, which may be formally derived from …

Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido [1, 6-a] pyrimidine and pyrimido [1, 6-c] pyrimidine scaffolds

KM Elattar, BD Mert, M Monier, A El-Mekabaty - RSC advances, 2020 - pubs.rsc.org
Heterocycles incorporating a pyrimidopyrimidine scaffold have aroused great interest from
researchers in the field of medical chemistry because of their privileged biological activities; …

Methods of synthesis for the azolo [1, 2, 4] triazines

EK Voinkov, RA Drokin, EN Ulomsky… - Chemistry of …, 2020 - Springer
The review summarizes and analyzes data from modern information sources on the
methods of synthesis of azolo [X, Yc][1, 2, 4] triazines. Approaches to the construction of the …

Recent advances in 1, 2, 4-triazolo [1, 5-a] pyrimidine chemistry

G Fischer - Advances in Heterocyclic Chemistry, 2019 - Elsevier
The review deals with the pharmaceutically and agrochemically important group of 1, 2, 4-
triazolo [1, 5-a] pyrimidines (TPs) and covers relevant literature published from about 2006 …

The most recent compilation of reactions of enaminone derivatives with various amine derivatives to generate biologically active compounds

TA Farghaly, AM Alosaimy… - Mini Reviews in …, 2024 - ingentaconnect.com
Heterocyclic derivatives serve as the fundamental components of both natural and synthetic
drugs. Enaminones play a crucial role as foundational units in the synthesis of numerous …

Stereoselective Oxidative Cyclization of N-Allyl Benzamides to Oxaz(ol)ines

AH Abazid, TN Hollwedel, BJ Nachtsheim - Organic letters, 2021 - ACS Publications
This study presents an enantioselective oxidative cyclization of N-allyl carboxamides via a
chiral triazole-substituted iodoarene catalyst. The method allows the synthesis of highly …

Design and Synthesis of Some New Quinoxaline‐Based Heterocycles

IH El Azab, NAA Elkanzi… - Journal of Heterocyclic …, 2018 - Wiley Online Library
Considering quinoxaline as a privileged structure for developing probes of impressive
therapeutic potentials, some new azole and azine conjugates of quinoxaline were …

4‐Chlorothiazole‐5‐carbaldehydes as Potent Precursors for Synthesis of Some New Pendant N‐heterocyces Endowed with Anti‐Tumor Activity

IH El Azab, AA Gobouri… - Journal of Heterocyclic …, 2019 - Wiley Online Library
In our approach to synthesize bioactive molecules, a series of novel N‐heterocycles were
synthesized and evaluated for their in vitro antitumor activity against a panel of three human …

Recent Developments in the Antimicrobial Potential of Some Nitrogenous Heterocycles and their SAR Studies: A Review

B Nehra, M Kumar, S Singh, V Chawla… - Current Medicinal …, 2024 - ingentaconnect.com
Background: Infection remains a significant global health concern, with millions of new
cases and deaths occurring due to infectious diseases. Currently, chemoprophylaxis and …

Recent Synthetic Approaches to N, N-Dimethyl-β-Ketoenamines

HM Gaber, ZA Muhammad, SM Gomha… - Current Organic …, 2017 - ingentaconnect.com
Background: N, N-dimethyl-β-ketoenamines have proven to be of biological interest and
provide an access to new class of biologically active heterocyclic compounds for biomedical …