Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Progress in alternative strategies to combat antimicrobial resistance: Focus on antibiotics

J Murugaiyan, PA Kumar, GS Rao, K Iskandar… - Antibiotics, 2022 - mdpi.com
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR),
continues to evolve and spread beyond all boundaries. As a result, infectious diseases have …

Unravelling the collateral damage of antibiotics on gut bacteria

L Maier, CV Goemans, J Wirbel, M Kuhn, C Eberl… - Nature, 2021 - nature.com
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the
composition of gut microbiota and causing dysbiosis and disease. Despite this well-known …

Bioaccumulation of therapeutic drugs by human gut bacteria

M Klünemann, S Andrejev, S Blasche, A Mateus… - Nature, 2021 - nature.com
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However,
the systematic mapping of the interactions between drugs and bacteria has only started …

Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota

AE Lindell, M Zimmermann-Kogadeeva… - Nature Reviews …, 2022 - nature.com
The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …

Defining and combating antibiotic resistance from One Health and Global Health perspectives

S Hernando-Amado, TM Coque, F Baquero… - Nature …, 2019 - nature.com
Several interconnected human, animal and environmental habitats can contribute to the
emergence, evolution and spread of antibiotic resistance, and the health of these contiguous …

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

M Tyers, GD Wright - Nature Reviews Microbiology, 2019 - nature.com
Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …

Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds

J Li, X Liu, L Tan, Z Cui, X Yang, Y Liang, Z Li… - Nature …, 2019 - nature.com
The application of photothermal therapy to treat bacterial infections remains a challenge, as
the high temperatures required for bacterial elimination can damage healthy tissues. Here …

Plasmid-mediated colistin-resistance genes: mcr

JH Liu, YY Liu, YB Shen, J Yang, TR Walsh… - Trends in …, 2024 - cell.com
Colistin is regarded as a last-line drug against serious infections caused by multidrug-
resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin …

Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …