Hybridization chain reaction: a versatile molecular tool for biosensing, bioimaging, and biomedicine

S Bi, S Yue, S Zhang - Chemical Society Reviews, 2017 - pubs.rsc.org
Developing powerful, simple and low-cost DNA amplification techniques is of great
significance to bioanalysis and biomedical research. Thus far, many signal amplification …

Hybridization chain reaction and its applications in biosensing

J Wu, J Lv, X Zheng, ZS Wu - Talanta, 2021 - Elsevier
To pursue the sensitive and efficient detection of informative biomolecules for bioanalysis
and disease diagnosis, a series of signal amplification techniques have been put forward …

Design strategies of AuNPs-based nucleic acid colorimetric biosensors

T Yang, Z Luo, Y Tian, C Qian, Y Duan - TrAC Trends in Analytical …, 2020 - Elsevier
Nucleic acids are important biomarkers related to diseases of cancer, infectious, and genetic
disorders. As a kind of indicator, gold nanoparticles (AuNPs) can generate colored signals …

Ultrasensitive, colorimetric detection of microRNAs based on isothermal exponential amplification reaction-assisted gold nanoparticle amplification

RD Li, BC Yin, BC Ye - Biosensors and Bioelectronics, 2016 - Elsevier
MicroRNAs (miRNAs) play important roles in a wide range of biological processes, and their
aberrant expressions are linked to a large number of human diseases and disorders. In this …

Rapid, multianalyte detection of opioid metabolites in wastewater

N Kumar, M Rana, M Geiwitz, NI Khan, M Catalano… - ACS …, 2022 - ACS Publications
By monitoring opioid metabolites, wastewater-based epidemiology (WBE) could be an
excellent tool for real-time information on the consumption of illicit drugs. A key limitation of …

Emerging isothermal amplification technologies for microRNA biosensing: Applications to liquid biopsies

G Gines, R Menezes, W Xiao, Y Rondelez… - Molecular Aspects of …, 2020 - Elsevier
The potential of microRNAs (miRNAs) as biomarker candidates in clinical practice for
diagnosis, prognosis and treatment response prediction, especially in liquid biopsies, has …

Highly sensitive detection of multiple microRNAs by high-performance liquid chromatography coupled with long and short probe-based recycling amplification

T Qi, C Song, J He, W Shen, D Kong, H Shi… - Analytical …, 2020 - ACS Publications
This report demonstrated the utility of high-performance liquid chromatography (HPLC)-
fluorescence detection for selective separation and sensitive quantification of multiple …

Chemical and biological sensing using hybridization chain reaction

EE Augspurger, M Rana, MV Yigit - ACS sensors, 2018 - ACS Publications
Since the advent of its theoretical discovery more than 30 years ago, DNA nanotechnology
has been used in a plethora of diverse applications in both the fundamental and applied …

Simple, amplified, and multiplexed detection of microRNAs using time-gated FRET and hybridization chain reaction

J Guo, C Mingoes, X Qiu, N Hildebrandt - Analytical chemistry, 2019 - ACS Publications
The hybridization chain reaction (HCR) is a simple and sensitive method for quantifying
nucleic acids. Current approaches cannot combine a washing-free sensing format with …

An unmodified gold nanorods-based DNA colorimetric biosensor with enzyme-free hybridization chain reaction amplification

C Xu, L Lan, Y Yao, J Ping, Y Li, Y Ying - Sensors and Actuators B …, 2018 - Elsevier
A novel and simple colorimetric biosensor was developed by combining the unique optical
properties of unmodified gold nanorods (AuNRs) with the amplification strategy of …