Cerebellar Purkinje cells exhibit a unique type of synaptic plasticity, namely, long-term
depression (LTD). When two inputs to a Purkinje cell, one from a climbing fiber and the other …

Communication between neurons in the brain occurs primarily through synapses made onto
elaborate treelike structures called dendrites. New electrical and optical recording …

NICOTINE obtained from tobacco can improve learning and memory on various tasks and
has been linked to arousal, attention, rapid information processing, working memory, and …

1 Simultaneous whole‐cell voltage and Ca2+ fluorescence measurements were made from
the distal apical dendrites and the soma of thick tufted pyramidal neurons in layer 5 of 4 …

We describe a method for determining intracellular free calcium concentration ([Ca 2+]) from
single-wavelength fluorescence signals. In contrast to previous single-wavelength …

1. A detailed compartmental model of a cerebellar Purkinje cell with active dendritic
membrane was constructed. The model was based on anatomic reconstructions of single …

Neostriatal cholinergic interneurons produce spontaneous tonic firing in the absence of
synaptic input. Perforated patch recording and whole-cell recording combined with calcium …

A key goal in neuroscience is to explain how the operations of a neuron emerge from sets of
active channels with specific dendritic distributions. If general principles can be identified for …

Calcium imaging using fura-2 and whole cell recording revealed the effective location of the
oscillator mechanism on dopaminergic neurons of the substantia nigra, pars compacta, in …

Synaptic plasticity is an important cellular mechanism for the formation of memory in
neuronal circuits of the brain. Research during the past two decades has revealed …