Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …

The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria,
indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ …

Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

The genetics and pathophysiology of Parkinson's disease (PD) strongly implicate
mitochondria in disease aetiology. Elegant studies over the last two decades have …

Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …

There has been long-term interest in drugging the PINK1-Parkin pathway with therapeutics
as a treatment for Parkinson's disease (PD). Despite significant structural data on Parkin as …

During the past few decades, considerable efforts have been made to discover and validate
new molecular mechanisms and biomarkers of neurodegenerative diseases. Recent …

Parkinson's disease is a neurodegenerative disorder characterised by cardinal motor
symptoms and a diverse range of non-motor disorders in patients. Parkinson's disease is the …