[HTML][HTML] Insulin action at a molecular level–100 years of progress
The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …
in the years since have marked a major turning point in the history of medicine. The …
Ferroptosis: death by lipid peroxidation
WS Yang, BR Stockwell - Trends in cell biology, 2016 - cell.com
Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair
enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based …
enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based …
Characterization of ferroptosis in kidney tubular cell death under diabetic conditions
Kidney tubular cell death induced by transforming growth factor-β1 (TGF-β1) is known to
contribute to diabetic nephropathy, a major complication of diabetes. Caspase-3-dependent …
contribute to diabetic nephropathy, a major complication of diabetes. Caspase-3-dependent …
Insulin action in brain regulates systemic metabolism and brain function
Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are
distributed throughout the brain. Insulin acts on these receptors to modulate peripheral …
distributed throughout the brain. Insulin acts on these receptors to modulate peripheral …
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
A Kleinridders, W Cai, L Cappellucci… - Proceedings of the …, 2015 - National Acad Sciences
Diabetes and insulin resistance are associated with altered brain imaging, depression, and
increased rates of age-related cognitive impairment. Here we demonstrate that mice with a …
increased rates of age-related cognitive impairment. Here we demonstrate that mice with a …
Huntington's disease: underlying molecular mechanisms and emerging concepts
J Labbadia, RI Morimoto - Trends in biochemical sciences, 2013 - cell.com
Huntington's disease (HD) is a progressive neurodegenerative disorder for which no
disease modifying treatments exist. Many molecular changes and cellular consequences …
disease modifying treatments exist. Many molecular changes and cellular consequences …
Polyglutamine-expanded huntingtin exacerbates age-related disruption of nuclear integrity and nucleocytoplasmic transport
F Gasset-Rosa, C Chillon-Marinas, A Goginashvili… - Neuron, 2017 - cell.com
Onset of neurodegenerative disorders, including Huntington's disease, is strongly influenced
by aging. Hallmarks of aged cells include compromised nuclear envelope integrity, impaired …
by aging. Hallmarks of aged cells include compromised nuclear envelope integrity, impaired …
Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis
K Dasuri, L Zhang, JN Keller - Free Radical Biology and Medicine, 2013 - Elsevier
Oxidative stress occurs in a variety of disease settings and is strongly linked to the
development of neuron death and neuronal dysfunction. Cells are equipped with numerous …
development of neuron death and neuronal dysfunction. Cells are equipped with numerous …
Insulin-like growth factor 1: at the crossroads of brain development and aging
S Wrigley, D Arafa, D Tropea - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Insulin-like growth factor 1 (IGF1) is a polypeptide hormone structurally similar to insulin. It is
central to the somatotropic axis, acting downstream of growth hormone (GH). It activates …
central to the somatotropic axis, acting downstream of growth hormone (GH). It activates …
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron disease with no current effective
treatment. Accumulation of abnormal protein inclusions containing SOD1, TARDBP, FUS …
treatment. Accumulation of abnormal protein inclusions containing SOD1, TARDBP, FUS …