Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

The adult zebrafish heart has a high capacity for regeneration following injury. However, the
composition of the regenerative niche has remained largely elusive. Here, we dissected the …

After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

Cardiovascular disease is the leading cause of death worldwide. Compared to other organs
such as the liver, the adult human heart lacks the capacity to regenerate on a macroscopic …

In the zebrafish (Danio rerio), regeneration and fibrosis after cardiac injury are not mutually
exclusive responses. Upon cardiac cryoinjury, collagen and other extracellular matrix (ECM) …

Although it is well accepted that the Notch signaling pathway is essential for vascular
morphogenesis, its contributions to the homeostasis of adult endothelium were uncovered …

Defective coronary network function and insufficient blood supply are both cause and
consequence of myocardial infarction. Efficient revascularization after infarction is essential …

Evolutionary developmental biology, or Evo-Devo for short, has become an established field
that, broadly speaking, seeks to understand how changes in development drive major …

With the high morbidity and mortality rates, cardiovascular diseases have become one of the
most concerning diseases worldwide. The heart of adult mammals can hardly regenerate …