The drug discovery process is a rocky path that is full of challenges, with the result that very
few candidates progress from hit compound to a commercially available product, often due …

Abstract Structure-based virtual screening is currently an established tool in drug lead
discovery projects. Although in the last years the field saw an impressive progress in terms …

Conventional orthosteric drug development programs targeting G protein-coupled receptors
(GPCRs) have focused on the concepts of agonism and antagonism, in which receptor …

GPCRs are the most successful pharmaceutical targets in history. Nevertheless, the
pharmacology of many GPCRs remains inaccessible as their endogenous or exogenous …

Rational drug design for G protein-coupled receptors (GPCRs) is limited by the small
number of available atomic resolution structures. We assessed the use of homology …

As currently postulated, a complex treatment may be key to an effective therapy for
Alzheimer's disease (AD). Recent clinical trials in patients with moderate AD have shown a …

The growing number of studies on G protein-coupled receptors (GPCRs) family are a source
of noticeable improvement in our understanding of the functioning of these proteins. GPCRs …

Modulation of multiple protein targets with a single compound is essential for the effective
treatment of central nervous system disorders. In our previous G protein-coupled receptor …

Alzheimer's disease (AD) is a major public health problem, which is due to its increasing
prevalence and lack of effective therapy or diagnostics. The complexity of the AD …

The lack of an effective treatment makes Alzheimer's disease a serious healthcare problem
and a challenge for medicinal chemists. Herein we report interdisciplinary research on novel …