Nutrition plays an essential role in the regulation of optimal immunological response, by
providing adequate nutrients in sufficient concentrations to immune cells. There are a large …

Enlarged fat cells in obese adipose tissue diminish capacity to store fat and are resistant to
the anti-lipolytic effect of insulin. Insulin resistance (IR)-associated S-nitrosylation of insulin …

Cholesterol metabolism has been linked to immune functions, but the mechanisms by which
cholesterol biosynthetic signaling orchestrates inflammasome activation remain unclear …

Industrialized society-caused dysregular human behaviors and activities such as
overworking, excessive dietary intake, and sleep deprivation lead to perturbations in the …

The sterol regulatory element binding proteins (SREBPs) are transcription factors that
govern cholesterol and fatty acid metabolism. We recently identified SPRING as a post …

Lipid metabolism is frequently perturbed in cancers, but the underlying mechanism is
unclear. We present comprehensive evidence that oncogene MYC, in collaboration with …

Sterol regulatory element-binding proteins (SREBPs) are transcription factors that control
lipid homeostasis. SREBP activation is regulated by a negative feedback loop in which …

Endoplasmic reticulum (ER) stress, a change in the ER homeostasis, leads to initiation of the
unfolded protein response (UPR). The primary functions of the UPR are to restore the ER's …

Mechanisms of lipid homeostasis and its impairment are of crucial importance for
atherogenesis, and their understanding is necessary for successful development of new …

ABSTRACT SCAP (SREBF chaperone) regulates SREBFs (sterol regulatory element
binding transcription factors) processing and stability, and, thus, becomes an emerging drug …