Human pluripotent stem cell mechanobiology: manipulating the biophysical microenvironment for regenerative medicine and tissue engineering applications

RG Ireland, CA Simmons - Stem Cells, 2015 - academic.oup.com
A stem cell in its microenvironment is subjected to a myriad of soluble chemical cues and
mechanical forces that act in concert to orchestrate cell fate. Intuitively, many of these …

A minireview of microfluidic scaffold materials in tissue engineering

A Tong, R Voronov - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
In 2020, nearly 107,000 people in the US needed a lifesaving organ transplant, but due to a
limited number of donors, only∼ 35% of them have actually received it. Thus, successful bio …

A hyperelastic model for simulating cells in flow

SJ Müller, F Weigl, C Bezold, C Bächer… - … and Modeling in …, 2021 - Springer
In the emerging field of 3D bioprinting, cell damage due to large deformations is considered
a main cause for cell death and loss of functionality inside the printed construct. Those …

Applications of fiber lasers for the development of compact photonic devices

R Mary, D Choudhury, AK Kar - IEEE Journal of Selected …, 2014 - ieeexplore.ieee.org
Ultrafast fiber lasers, with their distinct features of high stability, superior beam quality,
compactness and power scalability have revolutionized a variety of applications, ranging …

Single‐cell encapsulation via click‐chemistry alters production of paracrine factors from neural progenitor cells

B Oh, V Swaminathan, A Malkovskiy… - Advanced …, 2020 - Wiley Online Library
Extracellular matrix (ECM) properties affect multiple cellular processes such as cell survival,
proliferation, and protein synthesis. Thus, a polymeric‐cell delivery system with the ability to …

Compression generated by a 3D supracellular actomyosin cortex promotes embryonic stem cell colony growth and expression of Nanog and Oct4

J Du, Y Fan, Z Guo, Y Wang, X Zheng, C Huang… - Cell systems, 2019 - cell.com
Mechanical factors play critical roles in mammalian development. Here, we report that
colony-growing mouse embryonic stem cells (mESCs) generate significant tension on the …

Quantified forces between HepG2 hepatocarcinoma and WA07 pluripotent stem cells with natural biomaterials correlate with in vitro cell behavior

R Harjumäki, RWN Nugroho, X Zhang, YR Lou… - Scientific reports, 2019 - nature.com
In vitro cell culture or tissue models that mimic in vivo cellular response have potential in
tissue engineering and regenerative medicine, and are a more economical and accurate …

Artificial Neural Network-Aided Computational Approach for Mechanophenotyping of Biological Cells Using Atomic Force Microscopy

Y Kamble, A Raj, A Thakur - Journal of …, 2023 - asmedigitalcollection.asme.org
The artificial neural network (ANN) based models have shown the potential to provide
alternate data-driven solutions in disease diagnostics, cell sorting and overcoming AFM …

High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing

E Guzniczak, M Mohammad Zadeh, F Dempsey… - Scientific reports, 2017 - nature.com
Stem cell products, including manufactured red blood cells, require efficient sorting and
purification methods to remove components potentially harmful for clinical application …

Polyacrylamide hydrogels with rigidity-independent surface chemistry show limited long-term maintenance of pluripotency of human induced pluripotent stem cells on …

S Paiva, P Joanne, C Migdal, EL Soler… - ACS Biomaterials …, 2019 - ACS Publications
In general, cells are cultured and adapted to the in vitro rigidities of plastic or glass ranging
between 1 and 10 GPa, which is very far from physiological values that are mostly in the …