[HTML][HTML] Ionizing radiation-induced epigenetic modifications and their relevance to radiation protection

M Belli, MA Tabocchini - International journal of molecular sciences, 2020 - mdpi.com
The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …

[HTML][HTML] MicroRNA as a potential therapeutic molecule in cancer

J Szczepanek, M Skorupa, A Tretyn - Cells, 2022 - mdpi.com
Small noncoding RNAs, as post-translational regulators of many target genes, are not only
markers of neoplastic disease initiation and progression, but also markers of response to …

[HTML][HTML] Epigenetic modifications in colorectal cancer: molecular insights and therapeutic challenges

AG Vaiopoulos, KC Athanasoula… - Biochimica et Biophysica …, 2014 - Elsevier
Colorectal cancer, a leading cause of mortality worldwide, is a multistep disorder that results
from the alteration of genetic and epigenetic mechanisms under contextual influence …

Low-dose ionizing radiation exposure, oxidative stress and epigenetic programing of health and disease

S Tharmalingam, S Sreetharan… - Radiation …, 2017 - meridian.allenpress.com
Ionizing radiation exposure from medical diagnostic imaging has greatly increased over the
last few decades. Approximately 80% of patients who undergo medical imaging are …

[HTML][HTML] Epigenetic regulation in melanoma: facts and hopes

EF Giunta, G Arrichiello, M Curvietto, A Pappalardo… - Cells, 2021 - mdpi.com
Cutaneous melanoma is a lethal disease, even when diagnosed in advanced stages.
Although recent progress in biology and treatment has dramatically improved survival rates …

[HTML][HTML] Epigenetic mechanisms underlying prostate cancer radioresistance

C Macedo-Silva, R Benedetti, F Ciardiello… - Clinical …, 2021 - Springer
Radiotherapy (RT) is one of the mainstay treatments for prostate cancer (PCa), a highly
prevalent neoplasm among males worldwide. About 30% of newly diagnosed PCa patients …

Deciphering the epigenetic network in cancer radioresistance

A Cabrera-Licona, IX Pérez-Añorve… - Radiotherapy and …, 2021 - Elsevier
Radiotherapy, in addition to surgery and systemic chemotherapy, remains the core of the
current clinical management of cancer. Radioresistance is one of the major causes of …

Chromatin structure and radiation-induced DNA damage: from structural biology to radiobiology

C Lavelle, N Foray - The international journal of biochemistry & cell biology, 2014 - Elsevier
Genomic DNA in eukaryotic cells is basically divided into chromosomes, each consisting of
a single huge nucleosomal fiber. It is now clear that chromatin structure and dynamics play a …

[HTML][HTML] Prospects and feasibility of synergistic therapy with radiotherapy, immunotherapy, and DNA methyltransferase inhibitors in non-small cell lung cancer

C Jie, R Li, Y Cheng, Z Wang, Q Wu, C Xie - Frontiers in Immunology, 2023 - frontiersin.org
The morbidity and mortality of lung cancer are increasing, seriously threatening human
health and life. Non-small cell lung cancer (NSCLC) has an insidious onset and is not easy …

Involvement of non-coding RNAs in chemo-and radioresistance of colorectal cancer

D Fanale, M Castiglia, V Bazan, A Russo - Non-coding RNAs in Colorectal …, 2016 - Springer
Despite recent progress in understanding the cancer signaling pathways and in developing
new therapeutic strategies, however, the resistance of colorectal cancer (CRC) cells to …