[HTML][HTML] Thirty years of the International Banff Classification for Allograft Pathology: the past, present, and future of kidney transplant diagnostics
Abstract 2021 marks the 30th anniversary of the original development of the Banff
Classification of Kidney Allograft Pathology, when in August 1991 a group of pathologists …
Classification of Kidney Allograft Pathology, when in August 1991 a group of pathologists …
IgA nephropathy: an interesting autoimmune kidney disease
A Rajasekaran, BA Julian, DV Rizk - The American journal of the medical …, 2021 - Elsevier
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide. It is a leading cause of chronic kidney disease and progresses to end-stage …
worldwide. It is a leading cause of chronic kidney disease and progresses to end-stage …
A phase 2 trial of sibeprenlimab in patients with IgA nephropathy
Background A proliferation-inducing ligand (APRIL) is implicated in the pathogenesis of IgA
nephropathy. Sibeprenlimab is a humanized IgG2 monoclonal antibody that binds to and …
nephropathy. Sibeprenlimab is a humanized IgG2 monoclonal antibody that binds to and …
Effect of oral methylprednisolone on decline in kidney function or kidney failure in patients with IgA nephropathy: the TESTING randomized clinical trial
Importance The effect of glucocorticoids on major kidney outcomes and adverse events in
IgA nephropathy has been uncertain. Objective To evaluate the efficacy and adverse effects …
IgA nephropathy has been uncertain. Objective To evaluate the efficacy and adverse effects …
[HTML][HTML] Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National …
We present a consensus report pertaining to the improved clarity of definitions and
classification of glomerular lesions in lupus nephritis that derived from a meeting of 18 …
classification of glomerular lesions in lupus nephritis that derived from a meeting of 18 …
[HTML][HTML] Next-Generation Morphometry for pathomics-data mining in histopathology
Pathology diagnostics relies on the assessment of morphology by trained experts, which
remains subjective and qualitative. Here we developed a framework for large-scale …
remains subjective and qualitative. Here we developed a framework for large-scale …
Evaluating a new international risk-prediction tool in IgA nephropathy
SJ Barbour, R Coppo, H Zhang, ZH Liu… - JAMA internal …, 2019 - jamanetwork.com
Importance Although IgA nephropathy (IgAN) is the most common glomerulonephritis in the
world, there is no validated tool to predict disease progression. This limits patient-specific …
world, there is no validated tool to predict disease progression. This limits patient-specific …
[HTML][HTML] Safety, tolerability and efficacy of narsoplimab, a novel MASP-2 inhibitor for the treatment of IgA nephropathy
RA Lafayette, BH Rovin, HN Reich, JA Tumlin… - Kidney international …, 2020 - Elsevier
Introduction Narsoplimab is a human monoclonal antibody against mannan-associated
lectin-binding serine protease− 2 (MASP-2). Now in a phase 3 study, narsoplimab was …
lectin-binding serine protease− 2 (MASP-2). Now in a phase 3 study, narsoplimab was …
Prediction and risk stratification of kidney outcomes in IgA nephropathy
Rationale & Objective Immunoglobulin A nephropathy (IgAN) is common worldwide and has
heterogeneous phenotypes. Predicting long-term outcomes and stratifying risk are important …
heterogeneous phenotypes. Predicting long-term outcomes and stratifying risk are important …
Proteinuria reduction as a surrogate end point in trials of IgA nephropathy
IgA nephropathy (IgAN) is an important cause of ESKD for which there are no approved
therapies. A challenge for evaluating treatments for IgAN is the usual long time course for …
therapies. A challenge for evaluating treatments for IgAN is the usual long time course for …