Tissue immunity and responses to injury depend on the coordinated action and
communication among physiological systems. Here, we show that, upon injury, adaptive …

The majority of drug-related toxicities are idiosyncratic, with little pathophysiological insight
and mechanistic understanding. Pathway toxicology is an emerging field of toxicology in the …

In familial pulmonary arterial hypertension (FPAH), the autosomal dominant disease-
causing BMPR2 mutation is only 20% penetrant, suggesting that genetic variation provides …

Healing of skin wounds is a multi-step process involving the migration and proliferation of
basal keratinocytes in epidermis, which strongly express the water/glycerol-transporting …

Transforming growth factor β (TGFβ) is important in inflammation, angiogenesis,
reepithelialization and connective tissue regeneration during wound healing. We analyzed …

Hydra has a regenerative capacity that is not limited to individual organs but encompasses
the entire body. Various global and integrative genome, transcriptome and proteome …

Wound healing is delayed frequently in patients with diabetes. Proper keratinocyte migration
is an essential step during re-epithelialization. Impaired keratinocyte migration is a critical …

Regeneration of severed limbs in adult animals is restricted to urodele amphibians.
Mammals, including humans, have very limited regenerative capabilities and even with …

Platelet lysates (PL), which are derived from platelets, are cocktails of growth factors and
cytokines that can promote tissue regeneration. Until today, most studies have focused on …

Skin wounds need to be repaired rapidly after injury to restore proper skin barrier function.
Hydrogen peroxide (H2O2) is a conserved signaling factor that has been shown to promote …