We are in the midst of a golden age of uncovering defense systems against bacteriophages.
Apart from the fundamental interest in these defense systems, and revolutionary applications …

The principal biological function of bacterial and archaeal CRISPR systems is RNA-guided
adaptive immunity against viruses and other mobile genetic elements (MGEs). These …

Abstract The Clusters of Orthologous Genes (COG) database, also referred to as the
Clusters of Orthologous Groups of proteins, was created in 1997 and went through several …

Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life.
Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in …

Robust and precise transcript targeting in mammalian cells remains a difficult challenge
using existing approaches due to inefficiency, imprecision and subcellular …

The CRISPR-Cas type III-E RNA-targeting effector complex gRAMP/Cas7-11 is associated
with a caspase-like protein (TPR-CHAT/Csx29) to form Craspase (CRISPR-guided …

CRISPR–Cas systems of bacteria and archaea comprise chromosomal loci with typical
repetitive clusters and associated genes encoding a range of Cas proteins. Adaptation of …

CRISPR–Cas is a widespread adaptive immune system in bacteria and archaea that
protects against viral infection by targeting specific invading nucleic acid sequences …

Advances in our understanding of prokaryotic antiphage defense mechanisms in the past
few years have revealed a multitude of new cyclic nucleotide signaling molecules that play a …

Maximal growth rate is a basic parameter of microbial lifestyle that varies over several orders
of magnitude, with doubling times ranging from a matter of minutes to multiple days. Growth …