[HTML][HTML] Recent progress in treatment of hepatocellular carcinoma

Z Chen, H Xie, M Hu, T Huang, Y Hu… - American journal of …, 2020 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death
worldwide. In the past decade, there have been improvements in non-drug therapies and …

The p38 pathway: from biology to cancer therapy

A Martínez-Limón, M Joaquin, M Caballero… - International journal of …, 2020 - mdpi.com
The p38 MAPK pathway is well known for its role in transducing stress signals from the
environment. Many key players and regulatory mechanisms of this signaling cascade have …

Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets

XY Luo, KM Wu, XX He - Journal of Experimental & Clinical Cancer …, 2021 - Springer
Although hepatocellular carcinoma (HCC) is one of the deadliest health burdens worldwide,
few drugs are available for its clinical treatment. However, in recent years, major …

Integrating old and new paradigms of G1/S control

SM Rubin, J Sage, JM Skotheim - Molecular cell, 2020 - cell.com
Summary The Cdk-Rb-E2F pathway integrates external and internal signals to control
progression at the G1/S transition of the mammalian cell cycle. Alterations in this pathway …

Eukaryotic cell size control and its relation to biosynthesis and senescence

S Xie, M Swaffer, JM Skotheim - Annual review of cell and …, 2022 - annualreviews.org
The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …

Treatment for liver cancer: From sorafenib to natural products

S Man, C Luo, M Yan, G Zhao, L Ma, W Gao - European journal of …, 2021 - Elsevier
Liver cancer most commonly develops in patients with chronic liver disease, the etiology of
which includes viral hepatitis (B and C), alcohol, obesity, dietary carcinogens, and so forth …

E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers

HB Park, KH Baek - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory
module of various cellular processes such as cell proliferation, differentiation, and stress …

Functional roles of JNK and p38 MAPK signaling in nasopharyngeal carcinoma

LJW Pua, CW Mai, FFL Chung, ASB Khoo… - International journal of …, 2022 - mdpi.com
c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members integrate signals that affect proliferation, differentiation, survival, and migration in a …

[HTML][HTML] Adult neural stem cells are alerted by systemic inflammation through TNF-α receptor signaling

G Belenguer, P Duart-Abadia, A Jordán-Pla… - Cell stem cell, 2021 - cell.com
Adult stem cells (SCs) transit between the cell cycle and a poorly defined quiescent state.
Single neural SCs (NSCs) with quiescent, primed-for-activation, and activated cell …

Microbial imidazole propionate affects responses to metformin through p38γ-dependent inhibitory AMPK phosphorylation

A Koh, L Mannerås-Holm, NO Yunn, PM Nilsson… - Cell metabolism, 2020 - cell.com
Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual
variations in responses to this drug. Its mechanism of action is not fully understood, but …