Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …

When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. The swift recognition
and faithful repair of such damage is crucial for the maintenance of genomic stability, as well …

RING E3s comprise the largest family of ubiquitin (UB) and ubiquitin-like protein (UBL)
ligases. RING E3s typically promote UB or UBL transfer from the active site of an associated …

DNA double strand breaks need to be repaired in an organized fashion to preserve genomic
integrity. In the organization of faithful repair, histone ubiquitination plays a crucial role …

The Polycomb group of epigenetic enzymes represses expression of developmentally
regulated genes in many eukaryotes. This group includes the Polycomb repressive complex …

DNA double-strand breaks (DSBs) elicit a histone modification cascade that controls DNA
repair,,. This pathway involves the sequential ubiquitination of histones H1 and H2A by the …

Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to
the lysosome, and loss of autophagy has been linked to increased genome instability. Here …

A timely and accurate cellular response to DNA damage requires tight regulation of the
action of DNA damage response (DDR) proteins at lesions. A multitude of posttranslational …

Mutations in the E3 ubiquitin ligase RING domains of BRCA1/BARD1 predispose carriers to
breast and ovarian cancers. We present the structure of the BRCA1/BARD1 RING …