Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises
from the interaction of multiple factors including tobacco, alcohol consumption, and betel …

Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

PURPOSE The regimens approved for the treatment of advanced head and neck squamous
cell carcinoma are accessible to only 1%-3% of patients in low-and middle-income countries …

Head and neck squamous cell carcinoma (HNSCC) arises from the interplay of multiple
factors, such as smoking, alcohol consumption, and viral infections. Cisplatin-based …

A maximum-tolerated dose (MTD) reduces the drug-sensitive cell population, though it may
result in the competitive release of drug resistance. Alternative treatment strategies such as …

Objectives The aim of this pilot study is to identify the genetic factors that contribute to the
response of metronomic chemotherapy in head and neck squamous cell carcinoma …

The combination of low-dose methotrexate and celecoxib as metronomic chemotherapy
(MCT) is a novel therapy, believed to act by modulating the immune response, inhibiting …

Background Early palliative care (EPC) is an important aspect of cancer management but, to
our knowledge, has never been evaluated in patients with head and neck cancer. Hence …

Background Oral submucous fibrosis (OSF) and proliferative verrucous leukoplakia (PVL)
are established as oral potentially malignant disorders. Dual pathology of the two conditions …

Metronomic therapy is characterized by drug administration in a low-dose, repeated, and
regular manner without prolonged drug-free interval. The two main anticancer mechanisms …