Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

Neural tube defects are severe congenital malformations affecting around one in every 1000
pregnancies. An innovation in clinical management has come from the finding that closure of …

The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a
critical, evolutionarily conserved process during development and organogenesis. Analyses …

Planar polarity describes the coordinated polarisation of cells or structures in the plane of a
tissue. The patterning mechanisms that underlie planar polarity are well characterised in …

Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the
tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP …

It is fundamentally important that signaling gradients provide positional information to govern
morphogenesis of multicellular organisms. Morphogen gradients can generate different cell …

Congenital defects of neural tube closure (neural tube defects; NTDs) are among the
commonest and most severe disorders of the fetus and newborn. Disturbance of any of the …

More than 80 mutant mouse genes disrupt neurulation and allow an in-depth analysis of the
underlying developmental mechanisms. Although many of the genetic mutants have been …

Evaluation of the central nervous system (CNS) in the developing mouse presents unique
challenges, given the complexity of ontogenesis, marked structural reorganization over very …

In mammals, an example of planar cell polarity (PCP) is the uniform orientation of the hair
cell stereociliary bundles within the cochlea. The PCP pathway of Drosophila,,, refers to a …