Background Feature selection is an essential task in single-cell RNA-seq (scRNA-seq) data
analysis and can be critical for gene dimension reduction and downstream analyses, such …

Background The development of single-cell RNA sequencing (scRNA-seq) has enabled
scientists to catalog and probe the transcriptional heterogeneity of individual cells in …

Alzheimer's disease (AD) is an age-related disease, with loss of integrity of the blood–brain
barrier (BBB) being an early feature. Cellular senescence is one of the reported nine …

Recent advances in direct cell reprogramming have made possible the conversion of one
cell type to another cell type, offering a potential cell-based treatment to many major …

The pathogenesis of allograft (dys) function has been increasingly studied using 'omics'-
based technologies, but the focus on individual organs has created knowledge gaps that …

Understanding human endometrial dynamics in the establishment of endometrial receptivity
remains a challenge, which limits early diagnosis and treatment of endometrial-factor …

Characterizing cell identity in complex tissues such as the human retina is essential for
studying its development and disease. While retinal organoids derived from pluripotent stem …

Motivation With the recent surge of large-cohort scale single cell research, it is of critical
importance that analytical methods can fully utilize the comprehensive characterization of …

Background Single-cell RNA-sequencing (scRNA-seq) technologies enable the capture of
gene expression heterogeneity and consequently facilitate the study of cell-to-cell variability …

Single-cell RNA-sequencing (scRNA-seq) provides gene expression profiles of individual
cells from complex samples, facilitating the detection of cell type-specific marker genes. In …